How very small changes in the peptide sequence of
β-amyloids influence their redox properties. Electrochemical studies of copper complexes with Aβ(11-16) and pAβ(11-16)

Magdalena Zofia Wiloch; Martin Jönsson-Niedziółka

doi:10.26434/chemrxiv-2022-vz4cg-v2

Physical Chemistry

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How very small changes in the peptide sequence of β-amyloids influence their redox properties. Electrochemical studies of copper complexes with Aβ(11-16) and pAβ(11-16)

01 July 2022, Version 2

Working Paper

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Here we demonstrate a significant difference in redox behaviour of copper complexes with β-amyloids Aβ(11-x) and pAβ(11-x) which are models for important components of senile plaques. A small change in the peptide chain may enhance reactive oxygen species (ROS) formation which can severely damage nerve cells.

Keywords

Pyroglutamate-modified Amyloid-β

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Additional electrochemical data

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Additional electrochemical data and experimental details.

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Now Published

Very small changes in the peptide sequence alter the redox properties of Aβ(11–16)-Cu(II) and pAβ(11–16)-Cu(II) β-amyloid complexes

Magdalena Z. Wiloch, Martin Jönsson-Niedziółka journal article

Journal of Electroanalytical Chemistry , Volume 922

Print publication date: Oct, 2022

Version History

Jul 01, 2022 Version 2

Feb 08, 2022 Version 1

Version Notes

The manuscript has been updated with additional UV-Vis spectroscopy data, underlining the difference between the behaviour of the two peptides in the different electrolytes.

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The content is available under CC BY NC 4.0

DOI

10.26434/chemrxiv-2022-vz4cg-v2

Funding

Narodowe Centrum Nauki

2021/40/C/ST4/00090

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content