How very small changes in the peptide sequence of β-amyloids influence their redox properties. Electrochemical studies of Aβ(11-16) and pAβ(11-16) in two different electrolytes.

Magdalena Zofia Wiloch; Martin Jönsson-Niedziółka

doi:10.26434/chemrxiv-2022-vz4cg

Physical Chemistry

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How very small changes in the peptide sequence of β-amyloids influence their redox properties. Electrochemical studies of Aβ(11-16) and pAβ(11-16) in two different electrolytes.

08 February 2022, Version 1

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Abstract

Here we demonstrate a significant difference in redox behaviour of copper complexes with β-amyloids Aβ(11-x) and pAβ(11-x) which are models for important components of senile plaques. A small change in the peptide chain may enhance reactive oxygen species (ROS) formation which can severely damage nerve cells.

Keywords

Pyroglutamate-modified Amyloid-β

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Jul 01, 2022 Version 2

Feb 08, 2022 Version 1

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The content is available under CC BY NC 4.0

DOI

10.26434/chemrxiv-2022-vz4cg

Funding

Narodowe Centrum Nauki

2020/04/X/ST4/00022

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

How very small changes in the peptide sequence of β-amyloids influence their redox properties. Electrochemical studies of Aβ(11-16) and pAβ(11-16) in two different electrolytes.

Authors

Abstract

Keywords

Supplementary materials

Comments

Version History

Metrics

License

DOI

Funding

Author’s competing interest statement

Ethics

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