Spatially Controlled Glycocalyx Engineering for Growth Factor Patterning in Embryoid Bodies

19 August 2020, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Cell surface engineering with synthetic glycomimetic co-receptors for FGF2 was used to establish gradients of stem cells with enhanced FGF2 affinity in embryoid bodies (EBs). Gradient shape was controlled by pre-assembly of glycomimetics into nanoscale vesicles with tunable dimensions and EB penetrance.

Keywords

Glycocalyx Engineering
gradient formation
embryoid body
Glycomimetic
growth factor 2

Supplementary materials

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Title
EB remodeling SI chemarxiv
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