Patterning of Growth Factor Gradients in Embryoid Bodies via Extracellular Matrix-Assisted Glycocalyx Engineering

Matthew
R. Naticchia; Logan K. Laubach; honigfort Daniel J.; purcell Sean C.; Kamil Godula

doi:10.26434/chemrxiv.12755849.v1

Biological and Medicinal Chemistry

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Patterning of Growth Factor Gradients in Embryoid Bodies via Extracellular Matrix-Assisted Glycocalyx Engineering

04 August 2020, Version 1

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Abstract

Cell surface engineering with synthetic glycomimetic co-receptors for FGF2 was used to establish gradients of stem cells with enhanced FGF2 affinity in embryoid bodies (EBs). Gradient shape was controlled by pre-assembly of glycomimetics into nanoscale vesicles with tunable dimensions and EB penetrance.

Keywords

Glycocalyx Engineering

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EB matrix remodeling SI chemarxiv

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