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Biological and Medicinal Chemistry

Working Paper

PDTAC: Targeted photodegradation of GPX4 triggers Ferroptosis and potent antitumor immunity

Sijin Liu, Xi Zhao, Sufang Shui, Biao Wang, Yingxian Cui, Tairan Yuwen, Suwei Dong, Guoquan Liu

Version 1 posted 31 May 2022

470

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Biological and Medicinal Chemistry

Working Paper

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Gerd Bader, Klaus Rumpel, Thomas Gerstberger, Yunhai Cui, Peter Greb, Geraldine Garavel, Maximilian Scharnweber, Julian Fuchs, Gabriela Gremel, Paolo Chette, Stefan Hopf, Nicole Budano, Jörg Rinnenthal, Gerhard Gmaschitz, Emelyne Diers, Ross McLennan, Michael Roy, Claire Whitworth, Vesna Vetma, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby

Version 1 posted 01 February 2022

6,037

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4

Citations

Biological and Medicinal Chemistry

Working Paper

Targeted AURKA degradation: towards new therapeutic agents for neuroblastoma

Muhammad Rishfi, Simon Krols, Fien Martens, Ellen Sanders, Aline Eggermont, Fanny De Vloed, Joshua Robert Goulding, Martijn Risseeuw, Jan Molenaar, Frank Speleman, Bram De wilde, Serge Van Calenbergh, Kaat Durinck

Version 1 posted 19 August 2022

903

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Analytical Chemistry

Working Paper

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

Irene Ponzo, Alice Solda, Charlotte Crowe, Goran Dahl, Stefan Geschwindner, Alessio Ciulli, Ulrich Rant

Version 1 posted 06 March 2024

2,062

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Biological and Medicinal Chemistry

Working Paper

Selection of DNA-encoded Chemical Libraries for Compounds that can Induce Protein Ubiquitination

Cen Huang, Xingyuan Liu, Xinyuan Wu, Ling Meng, Xiaojie Lu, Xiaoyu Li

Version 1 posted 12 February 2024

1,314

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Biological and Medicinal Chemistry

Working Paper

Ternary Complex-Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo-PROTACs

Claudia Diehl, Alessandra Salerno, Alessio Ciulli

Version 2 posted 09 April 2024

1,365

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Biological and Medicinal Chemistry

Review

Molecular glues: The adhesive connecting targeted protein degradation to the clinic

Janet M. Sasso, Rumiana Tenchov, DaSheng Wang, Linda S. Johnson, Xinmei Wang, Qiongqiong Angela Zhou

Version 1 posted 16 June 2022

4,362

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

Adam G. Bond, Miquel Muñoz i Ordoño, Celia M. Bisbach, Conner Craigon, Nikolai Makukhin, Elizabeth A. Caine, Manjula Nagala, Marjeta Urh, Georg E. Winter, Kristin M. Riching, Alessio Ciulli

Version 1 posted 21 August 2024

2,263

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Organic Chemistry

Working Paper

Expedited Aminoglutarimide C-N Cross-Coupling Enabled by High-Throughput Experimentation

Jacqueline Gu, Martins Oderinde, Hui Li, Frederick Roberts, Jacob Ganley, Maximilian Palkowitz

Version 1 posted 26 August 2024

1,932

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Biological and Medicinal Chemistry

Working Paper

Bifunctional molecules that induce targeted degradation and transcytosis of extracellular proteins in brain cells

Rebecca Howell, Rinco Wang, David McDonald, David Spiegel

Version 2 posted 19 September 2023

766

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Refine Search

30 results in targeted protein degradation in Keywords: targeted protein degradation

PDTAC: Targeted photodegradation of GPX4 triggers Ferroptosis and potent antitumor immunity

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Targeted AURKA degradation: towards new therapeutic agents for neuroblastoma

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

Selection of DNA-encoded Chemical Libraries for Compounds that can Induce Protein Ubiquitination

Ternary Complex-Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo-PROTACs

Molecular glues: The adhesive connecting targeted protein degradation to the clinic

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

Expedited Aminoglutarimide C-N Cross-Coupling Enabled by High-Throughput Experimentation

Bifunctional molecules that induce targeted degradation and transcytosis of extracellular proteins in brain cells

30 results in Keywords: targeted protein degradation