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Organic Chemistry

Working Paper

Rapid Functionalization of Polycarbonates and Polyurethanes via Organocatalyzed SNAr

Eddy Wei Ping Tan, Yi Yan Yang, James Hedrick, Nathaniel Park

Version 1 posted 06 December 2024

206

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Biological and Medicinal Chemistry

Working Paper

Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles

Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin P. Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A. Laufer, Stefan Knapp, Daniel Dauch, Matthias Gehringer

Version 2 posted 25 March 2024

1,253

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Organic Chemistry

Working Paper

Machine Learning Meets Mechanistic Modelling for Accurate Prediction of Experimental Activation Energies

Kjell Jorner, Tore Brinck, Per-Ola Norrby, David Buttar

Version 1 posted 05 August 2020

1,128

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Organic Chemistry

Working Paper

A generally applicable quantitative reactivity model for nucleophilic aromatic substitution built from simple descriptors

Jingru Lu, Irina Paci, David Leitch

Version 1 posted 19 July 2022

896

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Organic Chemistry

Working Paper

Synthesis of Bench-Stable N-Quaternized Ketene N,O-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis

Danielle L. McConnell, Alisha M. Blades, Danielle Gomes Rodrigues, Phoebe V. Keyes, Justin C. Sonberg, Caitlin E. Anthony, Sofia Rachad, Olivia M. Simone, Caroline F. Sullivan, Jonathan D. Shapiro, Christopher C. Williams, Benjamin C. Schafer, Amy Glanzer, Holly Hutchinson, Ashley Thayaparan, Zoe Krevlin, Isabella Bote, Yasin Haffary, Sambat Bhandari, Jack A. Goodman, Max Majireck

Version 2 posted 26 July 2021

1,148

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Organic Chemistry

Working Paper

A revised synthesis of 6-alkoxy-2-aminopurines with late-stage convergence allowing for increased molecular complexity

Lavleen Mader, John Hayward, Lisa Porter, John Trant

Version 1 posted 06 May 2022

310

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Organic Chemistry

Working Paper

Synthesis of Highly Functionalized Diarylamines through an N-, C-Cascade Reaction via Ammonium Salts

Erika Linde, Berit Olofsson

Version 1 posted 18 April 2023

485

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Organic Chemistry

Working Paper

Diarylation of N- and O-nucleophiles through a metal-free cascade reaction

Erika Linde, David Bulfield, Gabriella Kervefors, Nibadita Purkait, Berit Olofsson

Version 1 posted 16 July 2021

730

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Inorganic Chemistry

Working Paper

Improved Synthesis of Icosahedral Carboranes Containing Exohedral B–c and C–c Bonds

Kierstyn P. Anderson, Harrison A. Mills, Chantel Mao, Kent O. Kirlikovali, Jonathan C. Axtell, Arnold L. Rheingold, Alexander Spokoyny

Version 1 posted 26 October 2018

651

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Biological and Medicinal Chemistry

Working Paper

Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

Stefan Gerstenecker, Lisa Haarer, Martin Schröder, Mark Kudolo, Martin P. Schwalm, Valentin Wydra, Ricardo Serafim, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Matthias Gehringer

Version 1 posted 15 July 2021

363

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14 results in nucleophilic aromatic substitution in Keywords: nucleophilic aromatic substitution

Rapid Functionalization of Polycarbonates and Polyurethanes via Organocatalyzed SNAr

Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles

Machine Learning Meets Mechanistic Modelling for Accurate Prediction of Experimental Activation Energies

A generally applicable quantitative reactivity model for nucleophilic aromatic substitution built from simple descriptors

Synthesis of Bench-Stable N-Quaternized Ketene N,O-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis

A revised synthesis of 6-alkoxy-2-aminopurines with late-stage convergence allowing for increased molecular complexity

Synthesis of Highly Functionalized Diarylamines through an N-, C-Cascade Reaction via Ammonium Salts

Diarylation of N- and O-nucleophiles through a metal-free cascade reaction

Improved Synthesis of Icosahedral Carboranes Containing Exohedral B–c and C–c Bonds

Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

14 results in Keywords: nucleophilic aromatic substitution