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Organic Chemistry

Working Paper

Contrasteric glycosylations of cotylenol and 1,2-diols by virtual linker selection

Dylan Snelson, Stephen Ting, Ryan Shenvi

Version 1 posted 12 September 2024

1,946

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Theoretical and Computational Chemistry

Working Paper

Linker-Mediated Domain Separation Enhances Cold Adaptation in Cellulases

Robbie Ge, Ning Ding, Yaoyukun Jiang, Zhongyue J. Yang

Version 1 posted 27 November 2024

48

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Biological and Medicinal Chemistry

Working Paper

Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents

Lukas Zeisel, Jan G. Felber, Karoline C. Scholzen, Carina Schmitt, Alexander J. Wiegand, Leonid Komissarov, Elias S. J. Arnér, Oliver Thorn-Seshold

Version 2 posted 10 October 2023

1,110

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Biological and Medicinal Chemistry

Working Paper

Drug–drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers

Hikaru Fujita, Sachiko Arai, Hiroshi Arakawa, Kana Hamamoto, Toshiyuki Kato, Tsubasa Arai, Nanaka Nitta, Kazuki Hotta, Natsuko Hosokawa, Takako Ohbayashi, Chiaki Takahashi, Yasuhide Inokuma, Ikumi Tamai, Seiji Yano, Munetaka Kunishima, Yoshihiro Watanabe

Version 2 posted 30 January 2024

350

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Organic Chemistry

Working Paper

A versatile entry to unnatural, disulfide-linked amino acids and peptides through the disulfuration of azlactones

Masaki Iwata, Yuzuki Takami, Hayato Asanuma, Kenya Hosono, Hibiki Ohno, Naohiko Yoshikai, Kazuya Kanemoto

Version 3 posted 23 October 2024

634

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Organic Chemistry

Working Paper

Sensitive RNA Synthesis Using Fluoride-Cleavable Groups for Linking and Amino Protection

Alexander Apostle, Manoj Perera, Daniel Middleton, Shiyue Fang

Version 1 posted 22 November 2024

139

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Biological and Medicinal Chemistry

Working Paper

Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic Conformational Changes

Alessandra Salerno, Lianne Wieske, Claudia Diehl, Alessio Ciulli

Version 1 posted 20 December 2024

590

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7 results in linker in Keywords: linker

Contrasteric glycosylations of cotylenol and 1,2-diols by virtual linker selection

Linker-Mediated Domain Separation Enhances Cold Adaptation in Cellulases

Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents

Drug–drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers

A versatile entry to unnatural, disulfide-linked amino acids and peptides through the disulfuration of azlactones

Sensitive RNA Synthesis Using Fluoride-Cleavable Groups for Linking and Amino Protection

Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic Conformational Changes

7 results in Keywords: linker