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Analytical Chemistry

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antibody-drug conjugate

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5 results in Keywords: antibody-drug conjugate

Analytical Chemistry

Enhanced payload localization in antibody-drug conjugates using a middle-down mass spectrometry approach with proton transfer charge reduction

Linda Lieu, Cynthia Nagy, Jingjing Huang, Christopher Mullen, Graeme McAlister, Vlad Zabrouskov, Kristina Srzentić, Kenneth Durbin, Rafael Melani, Luca Fornelli

Version 1 posted 27 June 2024

273

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Biological and Medicinal Chemistry

Development of Diazaborines as ROS Sensitive Linkers for the Construction of Stimuli-Responsive Antibody Drug Conjugates

Pedro Gois, João António, Joana Carvalho, Ana André, Joana Dias, Hélio Faustino, Ricardo Lopes, Luis Veiros, Gonçalo Bernardes, Frederico Silva

Version 1 posted 06 July 2021

922

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Biological and Medicinal Chemistry

Exo-Cleavable Linkers: A Paradigm Shift for Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates

Tomohiro Watanabe, Naoko Arashida, Tomohiro Fujii, Natsuki Shikida, Kenichiro Ito, Kazutaka Shimbo, Takuya Seki, Yusuke Iwai, Ryusuke Hirama, Noriko Hatada, Akira Nakayama, Tatsuya Okuzumi, Yutaka Matsuda

Version 1 posted 25 September 2023

1,123

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1

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Biological and Medicinal Chemistry

Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates

Christopher Marvin, Adrian Hobson, Michael McPherson, Theresa Dunstan, Thomas Vargo, Martin Hayes, Margaret Fettis, Agnieszka Bischoff, Lu Wang, Lu Wang, Axel Hernandez, Jr., Ying Jia, Jason Oh, Yu Tian

Version 1 posted 08 August 2023

1,366

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Biological and Medicinal Chemistry

Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents

Lukas Zeisel, Jan G. Felber, Karoline C. Scholzen, Carina Schmitt, Alexander J. Wiegand, Leonid Komissarov, Elias S. J. Arnér, Oliver Thorn-Seshold

Version 2 posted 10 October 2023

1,110

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