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Light-Activatable Photochemically Targeting Chimeras (PHOTACs) Enable the Optical Control of Targeted Protein Degradation of HDAC6

Silas Wurnig, Maria Hanl, Thomas Geiger, Shiyang Zhai, Ina Dressel, Dominika Pieńkowska, Radosław Nowak, Finn Kristian Hansen

Version 1 posted 09 December 2024

268

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Biological and Medicinal Chemistry

Working Paper

Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs

Miriam Girardini, Chiara Maniaci, Scott J. Hughes, Andrea Testa, Alessio Ciulli

Version 2 posted 19 February 2019

1,755

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Biological and Medicinal Chemistry

Working Paper

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Whitney L. Petrilli, Gregory Adam, Roman S. Erdmann, Pravien Abeywickrema, Viju Agnani, Xi Ai, Jen Baysarowich, Noel Byrne, John Caldwell, Wonsuk Chang, Edward DiNunzio, Zhe Feng, Rachel Ford, Sookhee Ha, Yongcheng Huang, Brian Hubbard, Jennifer M. Johnston, Michael Kavana, Jean-Marie Lisnock, Rui Liang, Jun Lu, Zhijian Lu, Juncai Meng, Peter Orth, Oksana Palyha, Gopal Parthasarathy, Scott P. Salowe, Sujata Sharma, Jennifer Shipman, Stephen Soisson, Alison Strack, Hyewon Youm, Kake Zhao, Debbie Zinc, Hratch Zokian, George Addona, Karen Akinsanya, James R. Tata, Yusheng Xiong, Jason E. Imbriglio

Version 1 posted 09 July 2019

1,094

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Organic Chemistry

Working Paper

Bifunctional Small Molecules That Mediate the Degradation of Extracellular Proteins

David Caianiello, Mengwen Zhang, Jason Ray, Jake Swartzel, Emily Branham, Egor Chirkin, Venkata Sabbasani, Angela Gong, David Mcdonald, Viswanathan Muthusamy, David Spiegel

Version 2 posted 04 August 2020

2,696

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Ternary Complex-Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo-PROTACs

Claudia Diehl, Alessandra Salerno, Alessio Ciulli

Version 2 posted 09 April 2024

1,365

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Biological and Medicinal Chemistry

Working Paper

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

Adam G. Bond, Miquel Muñoz i Ordoño, Celia M. Bisbach, Conner Craigon, Nikolai Makukhin, Elizabeth A. Caine, Manjula Nagala, Marjeta Urh, Georg E. Winter, Kristin M. Riching, Alessio Ciulli

Version 1 posted 21 August 2024

2,263

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Biological and Medicinal Chemistry

Working Paper

PHOTACs Enable Optical Control of Protein Degradation

Martin Reynders, Bryan Matsuura, Marleen Bérouti, Daniele Simoneschi, Antonio Marzio, Michele Pagano, Dirk Trauner

Version 2 posted 31 May 2019

3,322

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5

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Theoretical and Computational Chemistry

Working Paper

In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Junzhuo Liao, Xueqing Nie, Ilona Unarta, Spencer Ericksen, Weiping Tang

Version 3 posted 20 December 2021

2,063

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Biological and Medicinal Chemistry

Working Paper

Lysosome Targeting Chimeras (LYTACs) That Engage a Liver-Specific Asialoglycoprotein Receptor for Targeted Protein Degradation

Green Ahn, Steven Banik, Caitlyn L. Miller, Nicholas Riley, Jennifer R. Cochran, Carolyn Bertozzi

Version 1 posted 30 July 2020

3,577

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5

Citations

Biological and Medicinal Chemistry

Working Paper

Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins

Steven Banik, Kayvon Pedram, Simon Wisnovsky, Nicholas Riley, Carolyn Bertozzi

Version 2 posted 20 November 2019

11,600

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5

Citations

Refine Search

30 results in Targeted protein degradation in Keywords: Targeted protein degradation

Light-Activatable Photochemically Targeting Chimeras (PHOTACs) Enable the Optical Control of Targeted Protein Degradation of HDAC6

Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Bifunctional Small Molecules That Mediate the Degradation of Extracellular Proteins

Ternary Complex-Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo-PROTACs

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

PHOTACs Enable Optical Control of Protein Degradation

In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Lysosome Targeting Chimeras (LYTACs) That Engage a Liver-Specific Asialoglycoprotein Receptor for Targeted Protein Degradation

Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins

30 results in Keywords: Targeted protein degradation