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Organic Chemistry

Working Paper

Direct Heterocycle C–H Alkenylation via Dual Catalysis Using a Palladacycle Precatalyst: Multifactor Optimization and Scope Exploration Enabled by High-Throughput Experimentation

Nahiane Pipaon-Fernandez, Odhran Cruise, Sarah Easton, Justin Kaplan, John Woodard, Damian Hruszkewycz, David Leitch

Version 1 posted 11 October 2023

613

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1

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Organic Chemistry

Working Paper

Analysis of the change in molecular complexity of reaction products in process development activities at AstraZeneca over time.

George Karageorgis, James Douglas, Gareth Howell

Version 1 posted 17 May 2024

280

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1

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Organic Chemistry

Working Paper

The PMI Predictor - a Web App Enabling Green-by-Design Chemical Synthesis

Alina Borovika, Jacob Albrecht, Jun Li, Andrew S. Wells, Christiana Briddell, Barry R. Dillon, Louis J. Diorazio, James R. Gage, Fabrice Gallou, Stefan G. Koenig, Michael E. Kopach, David K. Leahy, Isamir Martinez, Martin Olbrich, Jared L. Piper, Frank Roschangar, Edward Sherer, Martin D. Eastgate

Version 1 posted 16 January 2019

2,158

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4

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Organic Chemistry

Working Paper

Optimized Synthesis of 7-Aza-Indazoles by Diels–Alder Cascade and Associated Process Safety

Nicolas Brach, Vincent Le Fouler, Vincent Bizet, Marian Lanz, Pascale Hoehn, Fabrice Gallou, Corinne Bailly, Michael Parmentier, Nicolas Blanchard

Version 1 posted 16 April 2020

511

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Organic Chemistry

Working Paper

PhactorTM – a High Throughput Experimentation Management System

Tim Cernak, Babak Mahjour

Version 1 posted 30 October 2020

1,738

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4

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Organic Chemistry

Working Paper

Evolving to an Ideal Synthesis of Molnupiravir, an Investigational Treatment for COVID-19

Tamas Benkovics, John McIntosh, Steven Silverman, Jongrock Kong, Peter Maligres, Tetsuji Itoh, Hao Yang, Mark Huffman, Deeptak Verma, Weilan Pan, Hsing-I Ho, Jonathan Vroom, Anders Knight, Jessica Hurtak, William Morris, Neil Strotman, Grant Murphy, Kevin Maloney, Patrick Fier

Version 1 posted 23 December 2020

12,613

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20

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Organic Chemistry

Working Paper

An Explosophore-Based Approach Towards the Prediction of Energetic Material Sensitivity Properties

Jonas Rein, Jonathan M. Meinhardt, Julie L. Hofstra Wahlman, Matthew S. Sigman, Song Lin

Version 2 posted 10 August 2021

1,591

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1

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Organic Chemistry

Working Paper

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

Brenden Derstine, John W. Tomlin, Cheryl Peck, Jule-Phillip Dietz, Brenden Herrera, Flavio S. P. Cardoso, Dinesh J. Paymode, Andrew C. Yue, Anthony J. Arduengo III, Till Opatz, David R. Snead, Rodger W. Stringham, D. Tyler McQuade, B. Frank Gupton

Version 1 posted 26 February 2020

2,283

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Organic Chemistry

Working Paper

Reinforcing the Supply Chain of COVID-19 Therapeutics with Expert-Coded Retrosynthetic Software

Yingfu Lin, Zirong Zhang, Babak Mahjour, Di Wang, Rui Zhang, Eunjae Shim, Andrew McGrath, Yuning Shen, Nadia Brugger, Rachel Turnbull, Shashi Jasty, Sarah Trice, Tim Cernak

Version 1 posted 07 August 2020

2,235

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9

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Organic Chemistry

Working Paper

Aiming for a Standardized Protocol for Preparing a Process Green Synthesis Report and for Ranking Multiple Synthesis Plans to a Common Target Product

john andraos

Version 1 posted 03 April 2019

380

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13 results in Process Chemistry in Keywords: Process Chemistry

Direct Heterocycle C–H Alkenylation via Dual Catalysis Using a Palladacycle Precatalyst: Multifactor Optimization and Scope Exploration Enabled by High-Throughput Experimentation

Analysis of the change in molecular complexity of reaction products in process development activities at AstraZeneca over time.

The PMI Predictor - a Web App Enabling Green-by-Design Chemical Synthesis

Optimized Synthesis of 7-Aza-Indazoles by Diels–Alder Cascade and Associated Process Safety

PhactorTM – a High Throughput Experimentation Management System

Evolving to an Ideal Synthesis of Molnupiravir, an Investigational Treatment for COVID-19

An Explosophore-Based Approach Towards the Prediction of Energetic Material Sensitivity Properties

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

Reinforcing the Supply Chain of COVID-19 Therapeutics with Expert-Coded Retrosynthetic Software

Aiming for a Standardized Protocol for Preparing a Process Green Synthesis Report and for Ranking Multiple Synthesis Plans to a Common Target Product

13 results in Keywords: Process Chemistry