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Analytical Chemistry

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Biological and Medicinal Chemistry

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Middle-down

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3 results in Keywords: Middle-down

Analytical Chemistry

Towards a universal method for middle-down analysis of antibodies via proton transfer charge reduction – Orbitrap mass spectrometry

Ryan Oates, Linda Lieu, Jake Kline, Christopher Mullen, Kristina Srzentić, Romain Huguet, Graeme McAlister, Jingjing Huang, David Bergen, Rafael Melani, Vlad Zabrouskov, Kenneth Durbin, John Syka, Luca Fornelli

Version 1 posted 27 June 2024

200

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Analytical Chemistry

Enhanced payload localization in antibody-drug conjugates using a middle-down mass spectrometry approach with proton transfer charge reduction

Linda Lieu, Cynthia Nagy, Jingjing Huang, Christopher Mullen, Graeme McAlister, Vlad Zabrouskov, Kristina Srzentić, Kenneth Durbin, Rafael Melani, Luca Fornelli

Version 1 posted 27 June 2024

154

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Analytical Chemistry

Digestion-Free Middle-down Mass Spectrometry Method for Absolute Quantification of Conjugated Payload from ADCs

Jiaqi Yuan, Hui Yin Tan, Yue Huang, Anton Rosenbaum

Version 2 posted 26 August 2024

370

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