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Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation

Zsófia Hegedüs Zsófia Hegedüs, Fruzsina Hobor, Deborah K. Shoemark, sergio Celis, Lu-Yun Lian, Chi Trinh, Richard Sessions, Thomas Edwards, Andrew Wilson

Version 1 posted 05 June 2020

538

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Biological and Medicinal Chemistry

Working Paper

Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

Andrew J. Whitehouse, Sherine E. Thomas, Karen P. Brown, Alexander Fanourakis, Daniel Chan, M. Daben J. Libardo, Vitor Mendes, Helena I. M. Boshoff, R. Andres Floto, Chris Abell, Tom. L. Blundell, Anthony Coyne

Version 1 posted 16 May 2019

596

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Biological and Medicinal Chemistry

Working Paper

Extensive Crystallographic Fragment-Based Approach to Design SARS CoV2 3CLpro Main Protease Inhibitors and Related Metadata

Sarfraz Ahmad, Iskandar Abdullah, Yean Kee Lee, Mamoona Nazir, Muhammad Usman Mirza, John F. Trant, Noorsaadah Binti Abd Rahman

Version 1 posted 11 January 2021

614

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1

Citations

Theoretical and Computational Chemistry

Working Paper

Systemic Evolutionary Chemical Space Exploration For Drug Discovery

Chong Lu, Shien Liu, Weihua Shi, Jun Yu, Zhou Zhou, Xiaoxiao Zhang, Xiaoli Lu, Faji Cai, Ning Xia, Yikai Wang

Version 1 posted 07 December 2021

775

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Biological and Medicinal Chemistry

Working Paper

Fragment tailoring strategy to design novel chemical entities as potential binders of novel corona virus main protease

Chinmayee Choudhury

Version 2 posted 27 April 2020

1,122

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Biological and Medicinal Chemistry

Review

Fragment-based approaches to identify RNA binders

Blessy M. Suresh, Amirhossein Taghavi, Jessica L. Childs-Disney, Matthew D. Disney

Version 1 posted 13 January 2023

745

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Biological and Medicinal Chemistry

Working Paper

A Formylglycine-Peptide for the Site-Directed Identification of Phosphotyrosine-Mimetic Fragments

Markus Tiemann, Eric Nawrotzky, Peter Schmieder, Leon Wehrhan, Silke Bergemann, Vera Martos, Christoph Arkona, Bettina G. Keller, Jörg Rademann

Version 1 posted 08 April 2022

235

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Biological and Medicinal Chemistry

Working Paper

Reversible Small Molecule pan-Ras Inhibitors Display Tunable Affinity for the Active and Inactive forms of Ras.

Charles Parry, Francesca Pellicano, Alexander W. Schüttelkopf, Kim Beyer, Justin Bower, Amy Bryson, Kenneth S. Cameron, Nichole M. Cerutti, Jonathan P. Clark, Stuart Davidson, Keneth Davies, Martin J. Drysdale, Jeffrey Engelman, Anna Estevan-Barber, Andrea Gohlke, Christopher H. Gray, Daniel A. Guthy, Min Hong, Alana Hopkins, Luke Hutchinson, Jennifer Konczal, Michel Maira, Duncan McArthur, Mokdad Mezna, Heather McKinnon, Ridvan Nepravishta, Nils Ostermann, Camila Pasquali, Katie Pollock, Angelo Pugliese, Nicholas Rooney, Niko Schmiedeberg, Paul Shaw, Camilo Velez-Vega, Christopher West, Ryan West, Frederic Zecri, John B. Taylor

Version 2 posted 14 November 2024

1,338

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Biological and Medicinal Chemistry

Working Paper

Expanding Bioactive Fragment Space with the Generated Database GDB-13s

Ye Buehler, Jean-Louis Reymond

Version 1 posted 19 July 2023

225

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Biological and Medicinal Chemistry

Working Paper

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer, David E. Heppner

Version 2 posted 19 September 2023

745

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1

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14 results in Fragment-Based Drug Discovery in Keywords: Fragment-Based Drug Discovery

Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation

Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

Extensive Crystallographic Fragment-Based Approach to Design SARS CoV2 3CLpro Main Protease Inhibitors and Related Metadata

Systemic Evolutionary Chemical Space Exploration For Drug Discovery

Fragment tailoring strategy to design novel chemical entities as potential binders of novel corona virus main protease

Fragment-based approaches to identify RNA binders

A Formylglycine-Peptide for the Site-Directed Identification of Phosphotyrosine-Mimetic Fragments

Reversible Small Molecule pan-Ras Inhibitors Display Tunable Affinity for the Active and Inactive forms of Ras.

Expanding Bioactive Fragment Space with the Generated Database GDB-13s

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

14 results in Keywords: Fragment-Based Drug Discovery