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  • Degraders
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4 results in Keywords: Degraders

Category: Biological and Medicinal Chemistry
,
Working Paper
, Title:

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

, Authors: Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy Murphy, Angus Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L. Daniels, Alessio Ciulli
Version 2 posted 20 October 2021
4,622
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Category: Biological and Medicinal Chemistry
,
Working Paper
, Title:

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable and Blood Brain Barrier Penetrant Prote-olysis Targeting Chimera Degrader of Leucine Rich Repeat Kinase 2

, Authors: Xingui Liu, Alexia Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian Ganley, Rui Moreira, Dario Alessi, Alessio Ciulli
Version 2 posted 13 July 2022
4,472
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1
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