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Biological and Medicinal Chemistry

Working Paper

Light-Activatable, 2,5-Disubstituted Tetrazoles for the Proteome-Wide Profiling of Aspartates and Glutamates in Living Bacteria

Kathrin Bach, Bert L. H. Beerkens, Patrick R. A. Zanon, Stephan M. Hacker

Version 1 posted 18 December 2019

874

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Biological and Medicinal Chemistry

Working Paper

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Saleta Vazquez-Rodriguez, Miranda Wright, Catherine Rogers, Adam Cribbs, Srikannathasan Velupillai, Martin Philpott, Henry Lee, James E. Dunford, Kilian Huber, Matthew B. Robers, Jim Vasta, Marie-Laetitia Thezenas, Sarah Bonham, Benedikt M. Kessler, James Bennett, Oleg Fedorov, Florence Raynaud, Adam Donovan, Julian Blagg, Vassilios Bavetsias, Udo Oppermann, Akane Kawamura, Paul Brennan

Version 1 posted 11 September 2018

889

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1

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Biological and Medicinal Chemistry

Working Paper

Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome

Patrick R. A. Zanon, Lisa Lewald, Stephan M. Hacker

Version 1 posted 20 September 2019

1,160

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Biological and Medicinal Chemistry

Working Paper

Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

Stefan Gerstenecker, Lisa Haarer, Martin Schröder, Mark Kudolo, Martin P. Schwalm, Valentin Wydra, Ricardo Serafim, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Matthias Gehringer

Version 1 posted 15 July 2021

363

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Biological and Medicinal Chemistry

Working Paper

Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor

Ricardo Serafim, André Santiago, Caio dos Reis, Jessica Takarada, Priscila Mezzomo, Katlin Massirer, Martin P. Schwalm, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Rafael Counago, Matthias Gehringer

Version 1 posted 20 May 2021

977

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Biological and Medicinal Chemistry

Working Paper

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

Alexander Bakker, Ioli Kotsogianni, Liza Mirenda, Verena Straub, Bogdan Florea, Richard van den Berg, Antonius Janssen, Nathaniel Martin, Mario van der Stelt

Version 1 posted 25 March 2022

473

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Organic Chemistry

Working Paper

Aryl Fluorosulfate-Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Julie E. Bolding, Pablo Martín-Gago, Nima Rajabi, Luke F. Gamon, Tobias N. Hansen, Michael Jonathan Davies, Christian Adam Olsen

Version 1 posted 23 February 2022

502

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1

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Biological and Medicinal Chemistry

Review

Systematic exploration of privileged warheads for covalent kinase drug discovery

Zheng Zhao, Philip E. Bourne

Version 1 posted 16 August 2022

1,684

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1

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Biological and Medicinal Chemistry

Working Paper

Competitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound

Claudia Schmidt, Michael Zollo, Riccardo Bonsignore, Angela Casini, Stephan M. Hacker

Version 1 posted 17 February 2022

431

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Biological and Medicinal Chemistry

Working Paper

Profiling the proteome-wide selectivity of diverse electrophiles

Patrick R. A. Zanon, Fengchao Yu, Patricia Musacchio, Lisa Lewald, Michael Zollo, Kristina Krauskopf, Dario Mrdović, Patrick Raunft, Thomas E. Maher, Marko Cigler, Christopher Chang, Kathrin Lang, F. Dean Toste, Alexey I. Nesvizhskii, Stephan M. Hacker

Version 2 posted 12 July 2021

10,827

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16

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17 results in Covalent inhibitors in Keywords: Covalent inhibitors

Light-Activatable, 2,5-Disubstituted Tetrazoles for the Proteome-Wide Profiling of Aspartates and Glutamates in Living Bacteria

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome

Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

Aryl Fluorosulfate-Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Systematic exploration of privileged warheads for covalent kinase drug discovery

Competitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound

Profiling the proteome-wide selectivity of diverse electrophiles

17 results in Keywords: Covalent inhibitors