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Efficacy and toxicity analysis of selective BET bromodomain inhibitors in models of inflammatory liver disease

Luke Doskey, Cole Scholtz, Nora Vail, Shalil Khanal, Amani Lee, Sai Giridhar Sarma Kandanur, Zachariah Hoell, Amelia Huehls, Mohamed Issa, Enis Kostallari, Sheng Cao, Joel Reid, Harmeet Malhi, Vijay Shah, william pomerantz

Version 1 posted 24 October 2024

78

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Biological and Medicinal Chemistry

Working Paper

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, huda zahid, zachary hoell, mikael ellingson, ke shi, Hideki Aihara, Daniel A. Harki, william pomerantz

Version 1 posted 23 April 2020

563

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Biological and Medicinal Chemistry

Working Paper

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

Alfredo Picado, Apirat Chaikuad, Carrow Wells, Safal Shrestha, William Zuercher, Julie E. Pickett, Frank Kwarcinski, Parvathi Sinha, Chandi de Silva, Reena Zutshi, Shubin Liu, Natarajan Kannan, Stefan Knapp, David Drewry, Tim Willson

Version 1 posted 07 July 2020

826

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Biological and Medicinal Chemistry

Working Paper

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells

Cécile Echalier, Anna Rutkowska, Douglas W. Thomson, Lee Edwards, Blandine McKay, Marcel Muelbaier, Carsten Schultz, Giovanna Bergamini

Version 1 posted 03 November 2020

312

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Biological and Medicinal Chemistry

Working Paper

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia P. Monteiro, James E. Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Farham, Adam Cribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschik, Srikannathasan Velupillai, Abdellalh Allali- Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew M Lewis, Kilian Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schüle, Masoud Vedadi, Cheryl Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul Brennan, Udo Oppermann

Version 2 posted 30 May 2019

1,096

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1

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Biological and Medicinal Chemistry

Working Paper

A CycloRGDf(Me-V) Analog as Chemical Probe to Study Integrins Function in Living Cells

Vojtech Kapras, Wyatt T. Slattery, Frederic Menard

Version 1 posted 13 January 2020

645

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Biological and Medicinal Chemistry

Working Paper

A fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells

Devon Field, Stuart Warriner, Megan Wright

Version 1 posted 09 September 2022

233

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Organic Chemistry

Working Paper

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

Carrow Wells, David Drewry, Julie E. Pickett, Alison D. Axtman

Version 2 posted 18 May 2020

915

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1

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Biological and Medicinal Chemistry

Working Paper

Improved Electrophile Design for Exquisite Covalent Molecule Selectivity

José Montaño, Brian Wang, Regan Volk, Virginia Garda, Balyn Zaro

Version 2 posted 16 November 2021

1,127

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Biological and Medicinal Chemistry

Working Paper

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

David H. Drewry, Frances M. Potjewyd, Jeffrey L. Smith, Rebekah J. Dickmander, Armin Bayati, Stefanie Howell, Sharon A. Taft-Benz, Mohammad Anwar Hossain, Mark T. Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman

Version 1 posted 27 April 2022

221

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16 results in Chemical probe in Keywords: Chemical probe

Efficacy and toxicity analysis of selective BET bromodomain inhibitors in models of inflammatory liver disease

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A CycloRGDf(Me-V) Analog as Chemical Probe to Study Integrins Function in Living Cells

A fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

Improved Electrophile Design for Exquisite Covalent Molecule Selectivity

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

16 results in Keywords: Chemical probe