Search

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

David H. Drewry, Frances M. Potjewyd, Jeffrey L. Smith, Rebekah J. Dickmander, Armin Bayati, Stefanie Howell, Sharon A. Taft-Benz, Mohammad Anwar Hossain, Mark T. Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman

Version 1 posted 27 April 2022

230

Downloads

Biological and Medicinal Chemistry

Working Paper

Discovery of a Potent and Selective Naphthyridine-based Chemical Probe for Casein Kinase 2

Zachary W. Davis-Gilbert, Andreas Krämer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, Udo Oppermann, David H. Drewry, Alison D. Axtman

Version 1 posted 21 December 2022

174

Downloads

Organic Chemistry

Working Paper

Thiomethyltetrazines are Reversible Covalent Cysteine Warheads whose Dynamic Behavior can be "Switched off” via Bioorthogonal Chemistry Inside Live Cells

Amanda Tallon, Yingrong Xu, Graham West, Christopher am Ende, Joseph Fox

Version 1 posted 02 May 2023

1,052

Downloads

Biological and Medicinal Chemistry

Working Paper

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells

Cécile Echalier, Anna Rutkowska, Douglas W. Thomson, Lee Edwards, Blandine McKay, Marcel Muelbaier, Carsten Schultz, Giovanna Bergamini

Version 1 posted 03 November 2020

322

Downloads

Biological and Medicinal Chemistry

Working Paper

Efficacy and toxicity analysis of selective BET bromodomain inhibitors in models of inflammatory liver disease

Luke Doskey, Cole Scholtz, Nora Vail, Shalil Khanal, Amani Lee, Sai Giridhar Sarma Kandanur, Zachariah Hoell, Amelia Huehls, Mohamed Issa, Enis Kostallari, Sheng Cao, Joel Reid, Harmeet Malhi, Vijay Shah, william pomerantz

Version 1 posted 24 October 2024

137

Downloads

Biological and Medicinal Chemistry

Working Paper

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia P. Monteiro, James E. Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Farham, Adam Cribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschik, Srikannathasan Velupillai, Abdellalh Allali- Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew M Lewis, Kilian Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schüle, Masoud Vedadi, Cheryl Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul Brennan, Udo Oppermann

Version 2 posted 30 May 2019

1,110

Downloads

1

Citations

Biological and Medicinal Chemistry

Working Paper

A CycloRGDf(Me-V) Analog as Chemical Probe to Study Integrins Function in Living Cells

Vojtech Kapras, Wyatt T. Slattery, Frederic Menard

Version 1 posted 13 January 2020

660

Downloads

Biological and Medicinal Chemistry

Working Paper

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, huda zahid, zachary hoell, mikael ellingson, ke shi, Hideki Aihara, Daniel A. Harki, william pomerantz

Version 1 posted 23 April 2020

570

Downloads

Biological and Medicinal Chemistry

Working Paper

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

Alfredo Picado, Apirat Chaikuad, Carrow Wells, Safal Shrestha, William Zuercher, Julie E. Pickett, Frank Kwarcinski, Parvathi Sinha, Chandi de Silva, Reena Zutshi, Shubin Liu, Natarajan Kannan, Stefan Knapp, David Drewry, Tim Willson

Version 1 posted 07 July 2020

851

Downloads

Biological and Medicinal Chemistry

Working Paper

Autoinducer-Fluorophore Conjugates Enable FRET in LuxR Proteins in Vitro and in Cells

Matthew Styles, Michelle Boursier, Margaret McEwan, Emma Santa, Margrith Mattmann, Betty Slinger, Helen Blackwell

Version 1 posted 17 February 2022

274

Downloads

Refine Search

16 results in Chemical probe in Keywords: Chemical probe

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

Discovery of a Potent and Selective Naphthyridine-based Chemical Probe for Casein Kinase 2

Thiomethyltetrazines are Reversible Covalent Cysteine Warheads whose Dynamic Behavior can be "Switched off” via Bioorthogonal Chemistry Inside Live Cells

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells

Efficacy and toxicity analysis of selective BET bromodomain inhibitors in models of inflammatory liver disease

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A CycloRGDf(Me-V) Analog as Chemical Probe to Study Integrins Function in Living Cells

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

Autoinducer-Fluorophore Conjugates Enable FRET in LuxR Proteins in Vitro and in Cells

16 results in Keywords: Chemical probe