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Dibromocarbene Addition to Bicyclo[1.1.0]butanes: A Facile Route to Substituted Bicyclo[1.1.1]pentanes

Flynn C. Attard, Andrii Slobodianyk, Roman Bychek, Yaroslav Panasiuk, Philipp Neigenfind, Luca Massaro, Vadym V. Levterov, Phil S. Baran, Pavel K. Mykhailiuk, Lara R. Malins

Version 1 posted 20 December 2024

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Biological and Medicinal Chemistry

Working Paper

Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups

Andrew Ecker, Dorothy Levorse, Daniel Victor, Matthew Mitcheltree

Version 1 posted 16 March 2022

3,249

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1

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Catalysis

Working Paper

Polysubstituted Benzene Bioisosteres and Beyond: Photochemical Access to Bicyclo[2.1.1]hexanes

Marius Reinhold, Justin Steinebach, Johannes Walker

Version 1 posted 13 March 2023

1,007

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3

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Organic Chemistry

Working Paper

Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes

Joseph Anderson, Darren Poole, Gemma Cook, John Murphy, Nicholas Measom

Version 1 posted 21 August 2023

1,262

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1

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Organic Chemistry

Working Paper

An “Ideal” Bioisoster of the para-substituted Phenyl Ring

Pavel Mykhailiuk, Vadym Levterov, Yaroslav Panasyuk, Kateryna Sahun, Olexander Stashkevich, Valentyn Badlo, Oleg Shablykin, Iryna Sadkova, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yuliia Holota, Julia Bas

Version 1 posted 25 January 2023

4,856

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2

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Biological and Medicinal Chemistry

Working Paper

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Nima Rajabi, Alexander L. Nielsen, Tobias N. Hansen, Huy T. Nguyen, Michael Bæk, Julie E. Bolding, Oskar Ø. Bahlke, Sylvester E. G. Petersen, Christian R. O. Bartling, Kristian Strømgaard, Christian Adam Olsen

Version 1 posted 24 November 2021

403

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Organic Chemistry

Working Paper

A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres

Soumitra Agasti, Frederic Beltran, Emma Pye, Nikolas Kaltsoyannis, Giacomo Crisenza, David Procter

Version 1 posted 23 March 2022

4,139

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12

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Organic Chemistry

Working Paper

Enolate addition to bicyclobutanes enables expedient access to 2-oxo-bicyclohexane scaffolds

Kyla Woelk, Kushal Dhake, Nathan Schley, David Leitch

Version 2 posted 11 October 2023

871

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Organic Chemistry

Working Paper

Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as orthodisubstituted benzene bioisosteres with improved biological activity

Pablo Garrido-Garcia, Irene Quiros, Paula Milan-Rois, Alvaro Somoza, Israel Fernandez, Thomas Rigotti, Mariola Tortosa

Version 1 posted 03 October 2023

1,536

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1

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Organic Chemistry

Working Paper

Boronic Acid with High Oxidative Stability and Utility in Biological Contexts

Brian Graham, Ian W. Windsor, Brian Gold, Ronald Raines

Version 1 posted 07 December 2020

708

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22 results in Bioisosteres in Keywords: Bioisosteres

Dibromocarbene Addition to Bicyclo[1.1.0]butanes: A Facile Route to Substituted Bicyclo[1.1.1]pentanes

Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups

Polysubstituted Benzene Bioisosteres and Beyond: Photochemical Access to Bicyclo[2.1.1]hexanes

Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes

An “Ideal” Bioisoster of the para-substituted Phenyl Ring

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres

Enolate addition to bicyclobutanes enables expedient access to 2-oxo-bicyclohexane scaffolds

Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as orthodisubstituted benzene bioisosteres with improved biological activity

Boronic Acid with High Oxidative Stability and Utility in Biological Contexts

22 results in Keywords: Bioisosteres