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Organic Chemistry

Working Paper

Investigation of the Reactivity of 1-Azido-3-Iodobicyclo[1.1.1]pentane under “Click” Reaction Conditions

Elisabeth Sitte, Brendan Twamley, nitika grover, Mathias O.. Senge

Version 1 posted 12 October 2020

508

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Organic Chemistry

Working Paper

Handling Fluorinated Gases as Solid Reagents Using Metal–Organic Frameworks

Kaitlyn Keasler, Mary Zick, Emily Stacy, Jaehwan Kim, Jung-Hoon Lee, Lida Aeindartehran, Tomce Runcevski, Phillip Milner

Version 1 posted 30 January 2023

1,101

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Organic Chemistry

Working Paper

C−F Bond Activation Enables Synthesis of Aryl Difluoromethyl Bicyclopentanes as Benzophenone-Type Bioisosteres

Mingshuo Chen, Yuang Cui, Xiaoping Chen, Rui Shang, Xiaheng Zhang

Version 1 posted 22 August 2023

1,518

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3

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Biological and Medicinal Chemistry

Working Paper

Bioisostere-conjugated fluorescent probes for live-cell protein imaging without non-specific organelle accumulation.

Takuya Kamikawa, Akari Hashimoto, Nozomi Yamazaki, Junya Adachi, Kazuya Kikuchi, Yuichiro Hori

Version 2 posted 29 December 2023

468

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Organic Chemistry

Working Paper

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Nils Frank, Jeremy Nugent, Bethany Shire, Helena Pickford, Patrick Rabe, Alistair Sterling, Tryfon Zarganes-Tzitzikas, Thomas Grimes, Amber Thompson, Russell Smith, Christopher Schofield, Paul Brennan, Fernanda Duarte, Edward Anderson

Version 1 posted 01 June 2022

2,694

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1

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Biological and Medicinal Chemistry

Working Paper

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

Han Wee Ong, Xuan Yang, Jeffery Smith, Rebekah Dickmander, Jason Brown, Tammy Havener, Sharon Taft-Benz, Stefanie Howell, Marcia Sanders, Jacob Capener, Rafael Couñago, Edcon Chang, Andreas Krämer, Nathaniel Moorman, Mark Heise, Alison Axtman, David Drewry, Timothy Willson

Version 1 posted 24 April 2024

216

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Organic Chemistry

Working Paper

Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho‐Substituted Benzenes

Oleh Smyrnov, Kostiantyn Melnykov, Olexandr Pashenko, Dmytro Volochnyuk, Serhiy Ryabukhin

Version 1 posted 18 January 2024

346

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1

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Organic Chemistry

Working Paper

Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Naphthyl Bioisosteres

Aidan Kerckhoffs, Maud Tregear, Pol Hernandez-Llado, Massimiliano Runfola, Holly Shearsmith, Nils Frank, Sarah Squire, Lee Moir, Kirsten Christensen, Fernanda Duarte, Kay Davies, Angela Russell

Version 1 posted 25 July 2024

1,363

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Biological and Medicinal Chemistry

Working Paper

The Effects on Lipophilicity of Replacing Oxygenated Functionality with Their Fluorinated Bioisosteres

Richard J. Glyn, Graham Pattison

Version 1 posted 13 April 2021

2,414

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Organic Chemistry

Working Paper

Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific SuFEx Reaction

Stephanie Greed, Edward L. Briggs, Fahima Idiris, Andrew J. P. White, Ulrich Lücking, James Bull

Version 1 posted 06 May 2020

739

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22 results in Bioisostere in Keywords: Bioisostere

Investigation of the Reactivity of 1-Azido-3-Iodobicyclo[1.1.1]pentane under “Click” Reaction Conditions

Handling Fluorinated Gases as Solid Reagents Using Metal–Organic Frameworks

C−F Bond Activation Enables Synthesis of Aryl Difluoromethyl Bicyclopentanes as Benzophenone-Type Bioisosteres

Bioisostere-conjugated fluorescent probes for live-cell protein imaging without non-specific organelle accumulation.

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho‐Substituted Benzenes

Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Naphthyl Bioisosteres

The Effects on Lipophilicity of Replacing Oxygenated Functionality with Their Fluorinated Bioisosteres

Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific SuFEx Reaction

22 results in Keywords: Bioisostere