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Biological and Medicinal Chemistry

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Antibody Drug Conjugates

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5 results in Keywords: Antibody Drug Conjugates

Biological and Medicinal Chemistry

Structure-Activity Relationships of Antibody-Drug Conjugates: A Systematic Review of Chemistry on the Trastuzumab Scaffold

Siddharth Matikonda, Ryan Mclaughlin, Pradeep Shrestha, Carol Lipshultz, Martin Schnermann

Version 1 posted 13 April 2022

1,518

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Biological and Medicinal Chemistry

Design, Synthesis, In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b targeted Antibody Drug Conjugates

Alan Zhang, Katherine Seiss, Sebastian Palacio-Ramirez, Laurent Laborde, Daniel Guthy, Mylene Lanter, Julien Lorber, Anna Vulpetti, Thomas Zoller, Christina Hebach, William R. Tschantz, Alexei Karpov, Gregory J. Hollingworth, Joseph A. D’Alessio, Stephane Ferretti, Matthew T. Burger

Version 1 posted 30 November 2023

1,478

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Biological and Medicinal Chemistry

A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates

Mathis Baalmann, Laura Neises, Sebastian Bitsch, Hendrik Schneider, Lukas Deweid, Nadja Ilkenhans, Martin Wolfring, Michael J. Ziegler, Philipp Werther, Jonas Wilhelm, Harald Kolmar, Richard Wombacher

Version 1 posted 26 November 2019

1,343

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Biological and Medicinal Chemistry

Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules

Adam Cotton, James Wells, Ian Seiple

Version 1 posted 06 January 2021

992

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Biological and Medicinal Chemistry

Alpha-Ammonium Carbamates Undergo Efficient Two-Step Linker Cleavage and Improve the Properties of Antibody Conjugates

Xiaoyi Li, Nimit Patel, Joseph Kalen, Martin Schnermann

Version 1 posted 06 June 2024

389

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