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Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying its Stability In Vivo

Yue Huang, Hui Yin Tan, Jiaqi Yuan, Ruipeng Mu, Junyan Yang, Kathryn Ball, Balakumar Vijayakrishnan, Luke Masterson, Krista Kinneer, Nadia Luheshi, Meina Liang, Anton Rosenbaum

Version 2 posted 08 August 2024

612

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Biological and Medicinal Chemistry

Working Paper

Monodisperse Polysarcosine-based Highly-loaded Antibody-Drug Conjugates

Warren Viricel, Guy Fournet, Sabine Beaumel, Emeline Perrial, Sébastien Papot, Charles Dumontet, Benoît Joseph

Version 2 posted 17 December 2018

1,076

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Theoretical and Computational Chemistry

Working Paper

Core-hole delocalization for modeling X-ray spectroscopies: A cautionary tale

Iulia Brumboiu, Thomas Fransson

Version 2 posted 13 May 2022

338

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Biological and Medicinal Chemistry

Review

Synthetic duocarmycins: structural evolution from SAR to prodrugs and ADCs - a searchable structure/function database

Jan Felber, Oliver Thorn-Seshold

Version 1 posted 04 August 2022

516

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Theoretical and Computational Chemistry

Working Paper

Using core-hole reference states for calculating X-ray photoelectron and emission spectra

Andreas Dreuw, Thomas Fransson

Version 2 posted 03 March 2022

275

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Physical Chemistry

Working Paper

XABOOM: An X-Ray Absorption Benchmark of Organic Molecules Based on Carbon, Nitrogen, and Oxygen 1s → π ∗ Transitions

Thomas Fransson, Iulia Emilia Brumboiu, Marta L. Vidal, Patrick Norman, Sonia Coriani, Andreas Dreuw

Version 2 posted 18 January 2021

845

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Biological and Medicinal Chemistry

Working Paper

Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents

Lukas Zeisel, Jan G. Felber, Karoline C. Scholzen, Carina Schmitt, Alexander J. Wiegand, Leonid Komissarov, Elias S. J. Arnér, Oliver Thorn-Seshold

Version 2 posted 10 October 2023

1,110

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Organic Chemistry

Working Paper

Investigating Multicomponent Approaches for the Site-Selective Conjugation of Native Proteins

Charlotte Sornay, Steve Hessmann, Stéphane Erb, Igor Dovgan, Anthony Ehkirch, Thomas Botzanowski, Sarah Cianferani, Alain Wagner, Guilhem Chaubet

Version 1 posted 12 March 2020

966

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Analytical Chemistry

Working Paper

Reference-Free Thio-Succinimide Isomerization Characterization by Electron-Activated Dissociation

Junyan Yang, Jiaqi Yuan, Yue Huang, Anton Rosenbaum

Version 3 posted 22 August 2024

322

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Analytical Chemistry

Working Paper

Enhanced payload localization in antibody-drug conjugates using a middle-down mass spectrometry approach with proton transfer charge reduction

Linda Lieu, Cynthia Nagy, Jingjing Huang, Christopher Mullen, Graeme McAlister, Vlad Zabrouskov, Kristina Srzentić, Kenneth Durbin, Rafael Melani, Luca Fornelli

Version 1 posted 27 June 2024

273

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11 results in ADC in Keywords: ADC

Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying its Stability In Vivo

Monodisperse Polysarcosine-based Highly-loaded Antibody-Drug Conjugates

Core-hole delocalization for modeling X-ray spectroscopies: A cautionary tale

Synthetic duocarmycins: structural evolution from SAR to prodrugs and ADCs - a searchable structure/function database

Using core-hole reference states for calculating X-ray photoelectron and emission spectra

XABOOM: An X-Ray Absorption Benchmark of Organic Molecules Based on Carbon, Nitrogen, and Oxygen 1s → π ∗ Transitions

Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents

Investigating Multicomponent Approaches for the Site-Selective Conjugation of Native Proteins

Reference-Free Thio-Succinimide Isomerization Characterization by Electron-Activated Dissociation

Enhanced payload localization in antibody-drug conjugates using a middle-down mass spectrometry approach with proton transfer charge reduction

11 results in Keywords: ADC