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Biological and Medicinal Chemistry

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Yusuke Iwai

4 results in Authors: Yusuke Iwai

Biological and Medicinal Chemistry

Biological Evaluation of Cleavable Linkers in Exatecan-Based Antibody-Drug Conjugates: A Comparative Study of DXd and Exo-Linker Platforms

Tomohiro Watanabe, Yusuke Iwai, Natsuki Shikida, Jason T. Stofleth, Takuya Seki, Kazutaka Shimbo, Yutaka Matsuda

Version 1 posted 24 December 2024

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Biological and Medicinal Chemistry

Exo-Cleavable Linkers: A Paradigm Shift for Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates

Tomohiro Watanabe, Naoko Arashida, Tomohiro Fujii, Natsuki Shikida, Kenichiro Ito, Kazutaka Shimbo, Takuya Seki, Yusuke Iwai, Ryusuke Hirama, Noriko Hatada, Akira Nakayama, Tatsuya Okuzumi, Yutaka Matsuda

Version 1 posted 25 September 2023

1,123

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1

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Biological and Medicinal Chemistry

Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second Generation

Tomohiro Fujii, Kenichiro Ito, Kazutoshi Takahashi, Tsubasa Aoki, Takuya Seki, Yusuke Iwai, Rika Takasugi, Tomohiro Watanabe, Ryusuke Hirama, Ryo Tsumura, Hirobumi Fuchigami, Masahiro Yasunaga, Yutaka Matsuda

Version 1 posted 25 August 2023

352

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Biological and Medicinal Chemistry

AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production

Tomohiro Fujii, Yutaka Matsuda, Takuya Seki, Natsuki Shikida, Yusuke Iwai, Yuri Ooba, Kazutoshi Takahashi, Muneki Isokawa, Sayaka Kawaguchi, Noriko Hatada, Tomohiro Watanabe, Rika Takasugi, Akira Nakayama, Kazutaka Shimbo, Brian. A. Mendelsohn, Tatsuya Okuzumi, Kei Yamada

Version 1 posted 31 January 2023

914

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2

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