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Organic Chemistry

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Enhanced Chemical Method for Bispecific Antibody Production: Leveraging Site-Specific Conjugation and Stable Crosslinker Technology

Tomohiro Fujii, Yutaka Matsuda

Version 2 posted 02 December 2024

219

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Physical Chemistry

Working Paper

Stacking Disorders in MixedAlkali Honeycomb Layered Oxide NaKNi2TeO6 and Feasibility for Mixed-Cation Transport

Titus Masese, Yoshinobu Miyazaki, Josef Rizell, Godwill Mbiti Kanyolo, Chih-Yao Chen, Hiroki Ubukata, Keigo Kubota, Kartik Sau, Tamio Ikeshoji, Zhen-Dong Huang, Kazuki Yoshii, Teruo Takahashi, Miyu Ito, Hiroshi Senoh, Jinkwang Hwang, Abbas Alshehabi, Kazuhiko Matsumoto, Masatomo Yashima, Kotaro Fujii, Toshiyuki Matsunaga, Masahiro Shikano, Yoshiharu Uchimoto, Cedric Tassel, Rika Hagiwara, Hiroshi Kageyama, Tomohiro Saito

Version 2 posted 30 March 2021

652

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Biological and Medicinal Chemistry

Working Paper

AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production

Tomohiro Fujii, Yutaka Matsuda, Takuya Seki, Natsuki Shikida, Yusuke Iwai, Yuri Ooba, Kazutoshi Takahashi, Muneki Isokawa, Sayaka Kawaguchi, Noriko Hatada, Tomohiro Watanabe, Rika Takasugi, Akira Nakayama, Kazutaka Shimbo, Brian. A. Mendelsohn, Tatsuya Okuzumi, Kei Yamada

Version 1 posted 31 January 2023

914

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2

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Biological and Medicinal Chemistry

Working Paper

Exo-Cleavable Linkers: A Paradigm Shift for Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates

Tomohiro Watanabe, Naoko Arashida, Tomohiro Fujii, Natsuki Shikida, Kenichiro Ito, Kazutaka Shimbo, Takuya Seki, Yusuke Iwai, Ryusuke Hirama, Noriko Hatada, Akira Nakayama, Tatsuya Okuzumi, Yutaka Matsuda

Version 1 posted 25 September 2023

1,123

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1

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Organic Chemistry

Working Paper

Gram-Scale Synthesis of Site-Specific Antibody-Drug Conjugates Using AJICAP Second-Generation Technology

Tomohiro Watanabe, Tomohiro Fujii, Jason Stofleth, Rika Takasugi, Kazutoshi Takahashi, Yutaka Matsuda

Version 1 posted 05 April 2023

605

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2

Citations

Biological and Medicinal Chemistry

Working Paper

Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second Generation

Tomohiro Fujii, Kenichiro Ito, Kazutoshi Takahashi, Tsubasa Aoki, Takuya Seki, Yusuke Iwai, Rika Takasugi, Tomohiro Watanabe, Ryusuke Hirama, Ryo Tsumura, Hirobumi Fuchigami, Masahiro Yasunaga, Yutaka Matsuda

Version 1 posted 25 August 2023

352

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Organic Chemistry

Working Paper

AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Specific Antibody-Drug Conjugate Synthesis

Yutaka Matsuda, Natsuki Shikida, Noriko Hatada, Kei Yamada, Takuya Seki, Yuichi Nakahara, Yuta Endo, Kazutaka Shimbo, Kazutoshi Takahashi, Akira Nakayama, Brian A. Mendelsohn, Tomohiro Fujii, Tatsuya Okuzumi, Shigeo Hirasawa

Version 1 posted 12 March 2024

711

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1

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Biological and Medicinal Chemistry

Working Paper

Exo-Linker: Positional Reconfiguration Driving Significant Advances in ADC Stability and Efficacy

Tomohiro Watanabe, Tomohiro Fujii, Yutaka Matsuda

Version 1 posted 04 December 2024

139

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8 results in Tomohiro Fujii in Authors: Tomohiro Fujii

Enhanced Chemical Method for Bispecific Antibody Production: Leveraging Site-Specific Conjugation and Stable Crosslinker Technology

Stacking Disorders in MixedAlkali Honeycomb Layered Oxide NaKNi2TeO6 and Feasibility for Mixed-Cation Transport

AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production

Exo-Cleavable Linkers: A Paradigm Shift for Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates

Gram-Scale Synthesis of Site-Specific Antibody-Drug Conjugates Using AJICAP Second-Generation Technology

Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second Generation

AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Specific Antibody-Drug Conjugate Synthesis

Exo-Linker: Positional Reconfiguration Driving Significant Advances in ADC Stability and Efficacy

8 results in Authors: Tomohiro Fujii