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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Whitney L. Petrilli, Gregory Adam, Roman S. Erdmann, Pravien Abeywickrema, Viju Agnani, Xi Ai, Jen Baysarowich, Noel Byrne, John Caldwell, Wonsuk Chang, Edward DiNunzio, Zhe Feng, Rachel Ford, Sookhee Ha, Yongcheng Huang, Brian Hubbard, Jennifer M. Johnston, Michael Kavana, Jean-Marie Lisnock, Rui Liang, Jun Lu, Zhijian Lu, Juncai Meng, Peter Orth, Oksana Palyha, Gopal Parthasarathy, Scott P. Salowe, Sujata Sharma, Jennifer Shipman, Stephen Soisson, Alison Strack, Hyewon Youm, Kake Zhao, Debbie Zinc, Hratch Zokian, George Addona, Karen Akinsanya, James R. Tata, Yusheng Xiong, Jason E. Imbriglio

Version 1 posted 09 July 2019

1,074

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Biological and Medicinal Chemistry

Working Paper

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Wei Shi, Guanghui Zong, Zhijian Hu, Sarah O’Keefe, Dale Tranter, Ludivine Baron, Michael Iannotti, Belinda Hall, Katherine Corfield, Anja Paatero, Mark Henderson, Peristera Roboti, Jianhong Zhou, Xianwei Sun, Mugunthan Govindarajan, Jason M. Rohde, Nicolas Blanchard, Rachel Simmonds, James Inglese, Yuchun Du, Caroline Demangel, Stephen High, Ville Paavilainen

Version 1 posted 14 January 2019

677

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Biological and Medicinal Chemistry

Working Paper

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases

Viivi H. A. Hirvonen, Katharine Hammond, Ewa I. Chudyk, Michael A. L. Limb, James Spencer, Adrian Mulholland, Marc W. van der Kamp

Version 1 posted 24 May 2019

482

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Biological and Medicinal Chemistry

Working Paper

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain

Michael Brand, James Clayton, Mustafa Moroglu, Matthias Schiedel, Sarah Picaud, Joseph Bluck, Anna Skwarska, Anthony Chan, Corentine Laurin, Amy Scorah, Larissa See, Timothy Rooney, Oleg Fedorov, Gabriella Perell, Prakriti Kalra, Wilian Cortopassi, Kirsten Christensen, Richard Cooper, Robert Paton, William Pomerantz, Philip Biggin, Ester M. Hammond, Panagis Filippakopoulos, Stuart Conway

Version 1 posted 06 April 2020

615

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3

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Earth, Space, and Environmental Chemistry

Working Paper

Selective Oxidation of Pharmaceuticals and Suppression of Perchlorate Formation during Electrolysis of Fresh Human Urine

James A. Clark, Yuhang Yang, Nathanael C. Ramos, Michael C. Dodd, Hugh W. Hillhouse

Version 2 posted 15 May 2020

874

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Materials Science

Working Paper

Impact Of Synthesis Route on the Water Oxidation Kinetics of Hematite Photoanodes

Camilo A. Mesa, Ludmilla Steier, Benjamin Moss, Laia Francàs, James E. Thorne, Michael Grätzel, James R Durrant

Version 1 posted 19 June 2020

710

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Organic Chemistry

Working Paper

Boron-Enabled Geometric Isomerization of Small Alkene Fragments via Selective Energy Transfer Catalysis

John James Molloy, Michael Schäfers, Max Wienhold, Tobias Morack, Constantin G. Daniliuc, Ryan Gilmour

Version 1 posted 16 March 2020

817

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Chemical Engineering and Industrial Chemistry

Working Paper

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

Jonas Rein, James R. Annand, Michael K. Wismer, Jiantao Fu, Juno C. Siu, Artis Klapars, Neil A. Strotman, Dipannita Kalyani, Dan Lehnherr, Song Lin

Version 2 posted 11 March 2021

1,502

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3

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Inorganic Chemistry

Working Paper

Rotaxane CoII Complexes as Field-Induced Single-Ion Magnets

Martina Cirulli, Enrico Salvadori, Zhi-Hui Zhang, Michael Dommett, Floriana Tuna, Heiko Bamberger, James Lewis, Amanpreet Kaur, Graham Tizzard, Joris van Slageren, Rachel Crespo Otero, Stephen Goldup, Maxie Roessler

Version 1 posted 18 March 2021

378

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Organic Chemistry

Working Paper

1,2-Difunctionalized Bicyclo[1.1.1]pentanes: Long Sought After Bioisosteres for ortho/meta-Substituted Arenes

Jin-Xin Zhao, Yuxuan Chang, Jeff Elleraas, T. Patrick Montgomery,, Jillian E. Spangler, Sajiv K. Nair, Matthew Del Bel, Gary M. Gallego, James J. Mousseau, Matthew A. Perry, Michael R. Collins, Julien Vantourout, Phil Baran

Version 1 posted 21 October 2020

3,789

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5

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79 results in Michael James in Authors: Michael James

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain

Selective Oxidation of Pharmaceuticals and Suppression of Perchlorate Formation during Electrolysis of Fresh Human Urine

Impact Of Synthesis Route on the Water Oxidation Kinetics of Hematite Photoanodes

Boron-Enabled Geometric Isomerization of Small Alkene Fragments via Selective Energy Transfer Catalysis

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

Rotaxane CoII Complexes as Field-Induced Single-Ion Magnets

1,2-Difunctionalized Bicyclo[1.1.1]pentanes: Long Sought After Bioisosteres for ortho/meta-Substituted Arenes

79 results in Authors: Michael James