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Biological and Medicinal Chemistry

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Maria Hanl

5 results in Authors: Maria Hanl

Biological and Medicinal Chemistry

Light-Activatable Photochemically Targeting Chimeras (PHOTACs) Enable the Optical Control of Targeted Protein Degradation of HDAC6

Silas Wurnig, Maria Hanl, Thomas Geiger, Shiyang Zhai, Ina Dressel, Dominika Pieńkowska, Radosław Nowak, Finn Kristian Hansen

Version 1 posted 09 December 2024

268

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Biological and Medicinal Chemistry

Hydrazide-based class I HDAC inhibitors with HDAC3 preference completely reverse chemoresistance in a synergistic manner in platinum-resistant solid cancer cells

Fabian B. Kraft, Lukas Biermann, Linda Schäker-Hübner, Maria Hanl, Alexandra Hamacher, Matthias U. Kassack, Finn Kristian Hansen

Version 2 posted 02 August 2024

365

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Biological and Medicinal Chemistry

Development and characterization of the first selective class IIb histone deacetylase degraders

Shiyang Zhai, Linda Schäker-Hübner, Maria Hanl, Lukas Jacobi, Dominika Ewa Pieńkowska, Jan Gerhartz, Rabea Voget, Michael Gütschow, Felix Meissner, Radosław P. Nowak, Christian Steinebach, Finn Kristian Hansen

Version 2 posted 28 August 2024

453

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Biological and Medicinal Chemistry

Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders

Felix Feller, Irina Honin, Martina Miranda, Heiko Weber, Svenja Henze, Maria Hanl, Finn Kristian Hansen

Version 1 posted 23 October 2024

422

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Biological and Medicinal Chemistry

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Daniel Stopper, Lukas Biermann, Paris Watson, jingyu Li, Beate König, Matthew Gaynes, Lais Pessanha de Carvalho, Maria Hanl, Alexandra Hamacher, Linda Schäker-Hübner, Jana Held, David Christianson, Matthias Kassack, Finn Kristian Hansen

Version 1 posted 01 October 2024

321

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