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Analytical Chemistry

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Linda Lieu

5 results in Authors: Linda Lieu

Analytical Chemistry

Top-down mass spectrometry analysis of capsid proteins of recombinant adeno-associated virus using multiple ion activations and proton transfer charge reduction

Jake Kline, Jingjing Huang, Linda Lieu, Kristina Srzentić, David Bergen, Christopher Mullen, Graeme McAlister, Kenneth Durbin, Rafael Melani, Luca Fornelli

Version 1 posted 27 June 2024

227

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Analytical Chemistry

Characterization of a monoclonal antibody by native and denaturing top-down mass spectrometry

Ryan Oates, Linda Lieu, Kristina Srzentić, Eugen Damoc, Luca Fornelli

Version 1 posted 28 May 2024

389

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Analytical Chemistry

Enhanced payload localization in antibody-drug conjugates using a middle-down mass spectrometry approach with proton transfer charge reduction

Linda Lieu, Cynthia Nagy, Jingjing Huang, Christopher Mullen, Graeme McAlister, Vlad Zabrouskov, Kristina Srzentić, Kenneth Durbin, Rafael Melani, Luca Fornelli

Version 1 posted 27 June 2024

273

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Analytical Chemistry

Leveraging ion-ion and ion-photon reactions to improve the sequencing of proteins carrying multiple disulfide bonds: the human serum albumin case study

Linda Lieu, Joshua Hinkle, John Syka, Luca Fornelli

Version 1 posted 28 June 2024

178

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Analytical Chemistry

Towards a universal method for middle-down analysis of antibodies via proton transfer charge reduction – Orbitrap mass spectrometry

Ryan Oates, Linda Lieu, Jake Kline, Christopher Mullen, Kristina Srzentić, Romain Huguet, Graeme McAlister, Jingjing Huang, David Bergen, Rafael Melani, Vlad Zabrouskov, Kenneth Durbin, John Syka, Luca Fornelli

Version 1 posted 27 June 2024

295

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