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7 results in Authors: Guangkuan Zhao

Organic Chemistry

Review

De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics

Stephane Roche, Guangkuan Zhao, Alexis Richaud, Thomas Williamson, Michael Feig

Version 1 posted 28 May 2024

149

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Biological and Medicinal Chemistry

Working Paper

A Platform of ADAPTive Scaffolds: Development of CDR-H3 -Hairpin Mimics into Covalent Inhibitors of the PD1/PDL1 Immune Checkpoint.

Sarah Naylon, Alexis Richaud, Guangkuan Zhao, Linda Bui, Craig Dufresne, Chunjing Wu, Medhi Wangpaichitr, Niramol Savaraj, Stephane Roche

Version 1 posted 31 May 2024

196

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Organic Chemistry

Working Paper

Mild Deprotection of Dithioacetals by TMSCl / NaI Association in CH3CN

Olivier Provot, Yunxin Yao, Guangkuan Zhao, Abdallah Hamze, Mouad Alami

Version 1 posted 04 June 2020

957

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Organic Chemistry

Working Paper

Synthesis of Quaternary -Amino Esters: A Remarkably Broad Substrate Scope in Aza-Friedel−Crafts Alkylation

Stephane Roche, Guangkuan zhao, Shyam Samanta, Jessica Michieletto

Version 1 posted 13 April 2020

745

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Citations

Organic Chemistry

Working Paper

Folding in Place: Design of β-Strap Motifs to Stabilize the Folding of Hairpins with Long Loops

Alexis Richaud, Guangkuan zhao, Stephane Roche, Samir Hobloss

Version 2 posted 03 February 2021

621

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Biological and Medicinal Chemistry

Working Paper

Bent to Bind: Exploiting the Programmed Cell Death-1 (PD-1) Receptor Plasticity to Design Pembrolizumab H3 Loop Mimics

Mehdi Zaghouani, Guangkuan zhao, Alexis Richaud, Medhi Wangpaichitr, Niramol Savaraj, Stephane Roche

Version 1 posted 26 April 2021

501

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Citations

Catalysis

Working Paper

Rh(III)-Catalyzed Direct Access to 2,3-Substituted β-N-Glycosyl Indoles Through C-H Activation/annulation Coupling of β-N-Aryl Glycosides with Substituted Internal Alkynes

Samir Messaoudi, Olivier Provot, Mouad Alami, Guangkuan Zhao, Mingxiang Zhu

Version 1 posted 29 October 2019

648

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7 results in Guangkuan Zhao in Authors: Guangkuan Zhao

De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics

A Platform of ADAPTive Scaffolds: Development of CDR-H3 -Hairpin Mimics into Covalent Inhibitors of the PD1/PDL1 Immune Checkpoint.

Mild Deprotection of Dithioacetals by TMSCl / NaI Association in CH3CN

Synthesis of Quaternary -Amino Esters: A Remarkably Broad Substrate Scope in Aza-Friedel−Crafts Alkylation

Folding in Place: Design of β-Strap Motifs to Stabilize the Folding of Hairpins with Long Loops

Bent to Bind: Exploiting the Programmed Cell Death-1 (PD-1) Receptor Plasticity to Design Pembrolizumab H3 Loop Mimics

Rh(III)-Catalyzed Direct Access to 2,3-Substituted β-N-Glycosyl Indoles Through C-H Activation/annulation Coupling of β-N-Aryl Glycosides with Substituted Internal Alkynes

7 results in Authors: Guangkuan Zhao