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Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells

Tiffany Gu, Rushika Raval, Zachary Bashkin, Carina Zhou, Sanghyuk Ko, Natalie Kong, Seoyeon Hong, Aditya Bhaskara, Samarth Shah, Aditi Joshi, Samahith Thellakal, Kaitlyn Rim, Anushree Marimuthu, Srishti Venkatesan, Emma Wang, Sophia Li, Aditi Jayabalan, Alice Tao, Yilin Fang, Lorelei Xia, Aidan Chui, Emily Shu, Tracy Zhang, Zhan Chen, Edward Njoo

Version 1 posted 16 October 2024

246

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Organic Chemistry

Working Paper

C-4 analogs of podophyllotoxin as tubulin inhibitors: Synthesis, biological evaluation, and structure-activity relationship

Breanna Lu, Lexi Xu, Harriet Chen, Grace Yu, Kimberly Khow, Stella Yang, Arushi Dinker, Edward Njoo

Version 1 posted 27 October 2023

474

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Theoretical and Computational Chemistry

Working Paper

Key Molecular Descriptors Distinguishing Between Synthetic and Natural Products

Nathaniel Thomas, Sweekrit Bhatnagar, Avirral Agarwal, Anya Iyer, Niranjana Sankar, Manav Bhargava, Spencer Ye, Edwin Li, Ritam Nandi, Edward Njoo, Robert Downing

Version 1 posted 03 October 2023

346

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Theoretical and Computational Chemistry

Working Paper

Evaluation of machine learning models for the accelerated prediction of Density Functional Theory calculated 19F chemical shifts based on local atomic environments

Sophia Li, Emma Wang, Leia Pei, Sourodeep Deb, Prashanth Prabhala, Sai Hruday Reddy Nara, Raina Panda, Shiven Eltepu, Marx Akl, Larry McMahan, Edward Njoo

Version 1 posted 31 July 2024

251

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Organic Chemistry

Working Paper

Benchtop 19F nuclear magnetic resonance spectroscopy enabled kinetic studies and optimization of the synthesis of carmofur

Xina Wang, Julia Vu, Charissa Luk, Edward Njoo

Version 1 posted 12 October 2022

385

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1

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Catalysis

Working Paper

Benchtop 19F nuclear magnetic resonance (NMR) spectroscopy provides mechanistic insight into the Biginelli condensation towards the chemical synthesis of novel trifluorinated dihydro- and tetrahydropyrimidinones as antiproliferative agents

Rosie Chen, Pratyush Singh, Sarah Su, Selin Kocalar, Xina Wang, Neha Mandava, Srishti Venkatesan, Adrienne Ferguson, Aishi Rao, Emma Le, Casey Rojas, Edward Njoo

Version 2 posted 07 December 2022

380

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Organic Chemistry

Working Paper

Benchtop 19F NMR Spectroscopy optimized Knorr pyrazole synthesis of Celecoxib and Mavacoxib, 3-(trifluoromethyl) pyrazolyl benzenesulfonamides Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Andrew Chyu, Selina Xi, Joshua Kim, Galen Liu, Indalina Chan, Seoyeon Hong, Allen Ke, Thomas Lavery, Anushree Marimuthu, Arjun Akula, Edward Njoo

Version 1 posted 03 October 2024

130

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7 results in Edward Njoo in Authors: Edward Njoo

Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells

C-4 analogs of podophyllotoxin as tubulin inhibitors: Synthesis, biological evaluation, and structure-activity relationship

Key Molecular Descriptors Distinguishing Between Synthetic and Natural Products

Evaluation of machine learning models for the accelerated prediction of Density Functional Theory calculated 19F chemical shifts based on local atomic environments

Benchtop 19F nuclear magnetic resonance spectroscopy enabled kinetic studies and optimization of the synthesis of carmofur

Benchtop 19F nuclear magnetic resonance (NMR) spectroscopy provides mechanistic insight into the Biginelli condensation towards the chemical synthesis of novel trifluorinated dihydro- and tetrahydropyrimidinones as antiproliferative agents

Benchtop 19F NMR Spectroscopy optimized Knorr pyrazole synthesis of Celecoxib and Mavacoxib, 3-(trifluoromethyl) pyrazolyl benzenesulfonamides Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

7 results in Authors: Edward Njoo