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Organic Chemistry

Working Paper

Accelerated SuFEx Click Chemistry for Modular Synthesis

Christopher J. Smedley, Timothy Gialelis, John Moses

Version 1 posted 25 January 2021

1,303

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Biological and Medicinal Chemistry

Working Paper

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides

Christopher J. Smedley, Bing Gao, Suhua Li, Qinheng Zheng, Andrew Molino, Hendrika M. Duivenvoorden, Belinda S. Parker, David J. D. Wilson, K. Barry Sharpless, John E. Moses

Version 3 posted 04 December 2018

1,404

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Biological and Medicinal Chemistry

Working Paper

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Qinheng Zheng, Jordan L. Woehl, Seiya Kitamura, Diogo Santos-Martins, Christopher J. Smedley, Gencheng Li, Stefano Forli, John E. Moses, Dennis W. Wolan, K. Barry Sharpless

Version 1 posted 15 March 2019

1,679

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2

Citations

Organic Chemistry

Working Paper

Metal-Free Click Synthesis of Functional 1-Substituted-1,2,3-Triazoles

Marie-Claire Giel, Christopher J. Smedley, Emily R. R. Mackie, Taijie Guo, Jiajia Dong, Tatiana P. Soares da Costa, John E. Moses

Version 1 posted 15 October 2019

1,092

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1

Citations

Organic Chemistry

Working Paper

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Yunfei Cheng, Gencheng Li, Christopher J. Smedley, Marie-Claire Giel, Seiya Kitamura, Jordan L. Woehl, Giulia Bianco, Stefano Forli, Joshua A. Homer, John R. Cappiello, Dennis W. Wolan, John E. Moses, K. Barry Sharpless

Version 1 posted 25 April 2022

653

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Catalysis

Working Paper

Phosphorus(V) Fluoride Exchange (PFEx): Multidimensional Click Chemistry from Phosphorus(V) Connective Hubs

Shoujun Sun, Christopher J. Smedley, Joshua A. Homer, Qing-Qing Cheng, K. Barry Sharpless, John E. Moses

Version 1 posted 03 October 2022

2,877

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1

Citations

Organic Chemistry

Working Paper

The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles using a Diversity Oriented Clicking Strategy

Joshua Kop, Carol Hua, Christopher J. Smedley

Version 1 posted 25 September 2024

219

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7 results in Christopher J. Smedley in Authors: Christopher J. Smedley

Accelerated SuFEx Click Chemistry for Modular Synthesis

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Metal-Free Click Synthesis of Functional 1-Substituted-1,2,3-Triazoles

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Phosphorus(V) Fluoride Exchange (PFEx): Multidimensional Click Chemistry from Phosphorus(V) Connective Hubs

The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles using a Diversity Oriented Clicking Strategy

7 results in Authors: Christopher J. Smedley