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Organic Chemistry

Working Paper

A 1-pot synthesis of the SARS-CoV-2 Mpro Inhibitor Nirmatrelvir, the key ingredient in Paxlovid

Juan Caravez, Karthik Iyer, Rahul Kavthe, Joseph Kincaid, Bruce Lipshutz

Version 1 posted 14 September 2022

455

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1

Citations

Catalysis

Working Paper

Preparation of a key intermediate en route to the anti-HIV drug lenacapavir

Bruce Lipshutz, Juan Caravez, Yuting Hu, Erfan Oftadeh, Kirabel Mamo

Version 1 posted 22 November 2023

818

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Catalysis

Working Paper

Switching to the non-PFAS-containing fluorosulfate leaving group, together with a Pd oxidative addition complex: rapid aminations of functionalized aromatics in water

Karthik Iyer, Kylee Dismuke Rodriguez, Robert Lammert, Jordan Yirak, John Saunders, Rahul Kavthe, Donald Aue, Bruce Lipshutz

Version 1 posted 13 May 2024

284

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Catalysis

Review

The impact of earth-abundant metals as a replacement for Pd in cross coupling reactions

Bruce Lipshutz, Fabrice Gallou, Michael Luescher

Version 1 posted 07 February 2024

615

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3

Citations

Catalysis

Working Paper

Introducing Savie: A Biodegradable Surfactant Enabling Chemo- and Bio-catalysis & Related Reactions in Recyclable Water

Joseph R. A. Kincaid, Madison J. Wong, Nnamdi Akporji, Fabrice Gallou, David M. Fialho, Bruce H. Lipshutz

Version 1 posted 24 November 2022

433

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1

Citations

Catalysis

Working Paper

Facile, green, and functional group-tolerant reductions of carboxylic acids…in water

Karthik Iyer, Chandler Nelson, Bruce Lipshutz

Version 1 posted 13 October 2022

788

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1

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Organic Chemistry

Working Paper

An Environmentally Responsible and Cost-effective Synthesis of the Antimalarial Drug Pyronaridine

Joseph R. A. Kincaid, Rahul D. Kavthe, Juan C. Caravez, Balaram S. Takale, Ruchita R. Thakore, Bruce H. Lipshutz

Version 1 posted 16 March 2022

296

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Organic Chemistry

Working Paper

A Sustainable Synthesis of the SARS-CoV-2 Mpro Inhibitor Nirmatrelvir, the Active Ingredient in Paxlovid

Joseph R. A. Kincaid, Juan C. Caravez, Karthik S. Iyer, Rahul D. Kavthe, Nico Fleck, Donald H. Aue, Bruce H. Lipshutz

Version 2 posted 14 July 2022

1,722

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1

Citations

Catalysis

Working Paper

Following Nature’s Lead. Designing a Very Simple yet Effective Ligand System Applicable to Pd-Catalyzed Cross Couplings…in Water

Bruce Lipshutz, Erfan Oftadeh, Max Baumann, Marco Ortiz, Kirubel Mamo, Eduam Boeira, Sam Nguyen, Donald Aue

Version 1 posted 14 October 2024

374

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9 results in Bruce Lipshutz in Authors: Bruce Lipshutz

A 1-pot synthesis of the SARS-CoV-2 Mpro Inhibitor Nirmatrelvir, the key ingredient in Paxlovid

Preparation of a key intermediate en route to the anti-HIV drug lenacapavir

Switching to the non-PFAS-containing fluorosulfate leaving group, together with a Pd oxidative addition complex: rapid aminations of functionalized aromatics in water

The impact of earth-abundant metals as a replacement for Pd in cross coupling reactions

Introducing Savie: A Biodegradable Surfactant Enabling Chemo- and Bio-catalysis & Related Reactions in Recyclable Water

Facile, green, and functional group-tolerant reductions of carboxylic acids…in water

An Environmentally Responsible and Cost-effective Synthesis of the Antimalarial Drug Pyronaridine

A Sustainable Synthesis of the SARS-CoV-2 Mpro Inhibitor Nirmatrelvir, the Active Ingredient in Paxlovid

Following Nature’s Lead. Designing a Very Simple yet Effective Ligand System Applicable to Pd-Catalyzed Cross Couplings…in Water

9 results in Authors: Bruce Lipshutz