Search

8 results in Authors: Axel Pahl

Biological and Medicinal Chemistry

Working Paper

Spacial Score – A Comprehensive Topological Indicator for Small Molecule Complexity

Adrian Krzyzanowski, Axel Pahl, Michael Grigalunas, Herbert Waldmann

Version 1 posted 30 March 2023

371

Downloads

Biological and Medicinal Chemistry

Working Paper

Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3-Rich Compounds With Distinct Phenotypic Effects

Ephraim Okolo, Axel Pahl, Sonja Sievers, Christopher Pask, Adam Nelson, Stephen Marsden

Version 1 posted 09 December 2022

314

Downloads

Theoretical and Computational Chemistry

Working Paper

A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds

A. Lina Heinzke, Barbara Zdrazil, Paul D. Leeson, Robert J. Young, Axel Pahl, Herbert Waldmann, Andrew R. Leach

Version 2 posted 11 March 2024

655

Downloads

Citations

Biological and Medicinal Chemistry

Working Paper

Pseudo-Natural Products Occur Frequently in Biologically Relevant Compounds

Herbert Waldmann, José-Manuel Gally, Axel Pahl, Paul Czodrowski

Version 1 posted 27 July 2021

531

Downloads

Biological and Medicinal Chemistry

Working Paper

Discovery of a novel pseudo-natural product Aurora kinase inhibitor chemotype through morphological profiling

Herbert Waldmann, Lin Wang, Furkan Yilmaz, Okan Yildirim, Beate Schölermann, Sukdev Bag, Luca Greiner, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Daniel Foley, Slava Ziegler, Michael Grigalunas

Version 1 posted 22 November 2023

709

Downloads

Biological and Medicinal Chemistry

Working Paper

Occurrence of ‘Natural Selection’ in Successful Small Molecule Drug Discovery

Lina Heinzke, Axel Pahl, Barbara Zdrazil, Andrew Leach, Herbert Waldmann, Robert Young, Paul Leeson

Version 1 posted 25 March 2024

454

Downloads

Biological and Medicinal Chemistry

Working Paper

Identification of Lysosomotropism using Explainable Machine Learning and Morphological Profiling Cell Painting Data

Aishvarya Tandon, Anna Santura, Axel Pahl, Herbert Waldmann, Paul Czodrowski

Version 2 posted 08 December 2023

679

Downloads

Biological and Medicinal Chemistry

Working Paper

Identification of Readily Available Pseudo-Natural Products

Axel Pahl, Oleksandr O. Grygorenko, Ivan S. Kondratov, Herbert Waldmann

Version 1 posted 27 March 2024

330

Downloads

Search

Refine Search

8 results in Axel Pahl in Authors: Axel Pahl

Spacial Score – A Comprehensive Topological Indicator for Small Molecule Complexity

Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3-Rich Compounds With Distinct Phenotypic Effects

A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds

Pseudo-Natural Products Occur Frequently in Biologically Relevant Compounds

Discovery of a novel pseudo-natural product Aurora kinase inhibitor chemotype through morphological profiling

Occurrence of ‘Natural Selection’ in Successful Small Molecule Drug Discovery

Identification of Lysosomotropism using Explainable Machine Learning and Morphological Profiling Cell Painting Data

Identification of Readily Available Pseudo-Natural Products

8 results in Authors: Axel Pahl