Synthesis of Conjugated Linear and Cyclic Polyynes by Alkyne Metathesis

27 March 2025, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The formation of polyynes with an odd number of conjugated triple bonds is synthetically demanding. To address this problem, we have developed and optimized the synthesis of triynes via alkyne metathesis of diynes using molybdenum catalysts. We demonstrate the potential of this method through the synthesis of more challenging and complex products, including macrocycles containing triynes, a pentayne, and triyne precursors to [7]cumulenes. The key to the success of the proposed methodology is achieving a balance between the selectivity and reactivity of the molybdenum and diyne precursors, which requires optimization of both steric hindrance and electronic factors.

Keywords

alkyne metathesis
triyne
pentayne
macrocycle
cumulene

Supplementary materials

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Description
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Electronic supporting information
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Synthetic procedures, NMR spectra, X-ray structures
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