Abstract
The topologically intriguing multimacrocyclic architecture is endowed with distinct physical and chemical properties. The synthesis of hybrid macrocycles combining crown ethers and cycloparaphenylenes (CPPs) presents a promising strategy for developing multifunctional supramolecular systems. Herein, we first report the precise construction of a series of crown ether-CPP hybrid multimacrocycles with enhanced photophysical properties and diverse host-guest interactions. Notably, the trimacrocyclic hybrid adopts a molecular tweezer-like conformation, leading to a five-fold increase in fullerene binding affinity compared to the bismacrocycle. Additionally, the bismacrocycle exhibits significant cytotoxicity against cancer cell lines at low concentrations and enables fluorescence-based detection of inflammatory responses, highlighting its potential for biosensing applications. These findings underscore the versatility of crown ether-CPP hybrid macrocycles in supramolecular chemistry and biochemistry, offering new avenues for the design of functional nanomaterials.
Supplementary materials
Title
SI
Description
Synthesis, NMR, and HRMS
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