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Abstract
A two-step, biocompatible strategy enables site-specific generation of branched and macrocyclic peptide–protein conjugates. Surface-exposed cysteines on proteins are modified by a small bifunctional reagent at near-physiological pH, followed by cyanopyridine–aminothiol click reactions to create branched or macrocyclic peptide architectures. This method offers design strategies for next-generation protein therapeutics.
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