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Abstract
A copper-catalyzed efficient, operationally simple, general method for straightforward syntheses of spirocyclic compounds employing EMCCs (ethynyl methylene cyclic carbamates) as precursors reacting with different nucleophilic reagents was firstly reported. This transformation features mild reaction conditions, broad functional group tolerance, and an extensive substrate scope, thereby facilitating the efficient construction of an array of spirocyclic compounds. In addition, a scale-up experiment further highlighted the synthetic utility.
Supplementary materials
Title
Cu(I)-Catalyzed Reaction of Ethynyl Methylene Cyclic Carbamates : Synthesis of Spirocyclic Compounds
Description
A copper-catalyzed efficient, operationally simple, general method for straightforward syntheses of spirocyclic compounds employing EMCCs (ethynyl methylene cyclic carbamates) as precursors reacting with different nucleophilic reagents was firstly reported. This transformation features mild reaction conditions, broad functional group tolerance, and an extensive substrate scope, thereby facilitating the efficient construction of an array of spirocyclic compounds. In addition, a scale-up experiment further highlighted the synthetic utility.
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