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Diastereoselective Anomeric C(sp3)-H Cyclization Towards the Design of New Generations of Cyclophane-Braced Glycopeptides

13 September 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Here we report a macrocyclization route towards the synthesis of glycophane peptides by a selective C-H arylation of the anomeric bond. This approach demonstrates the power of Pd-catalysis C-H activation to access unfamiliar cyclic peptides

Supplementary materials

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Title
Diastereoselective Anomeric C(sp3)-H Cyclization Towards the Design of New Generations of Cyclophane-Braced Glycopeptides
Description
Supporting Information, NMR spectra, DFT calculation,
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Version History

Sep 13, 2024 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-zgxwt
D O I: 10.26434/chemrxiv-2024-zgxwt [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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