Grignard Reagents as Simple Catalysts for the Dehydrocoupling of Amines and Silanes

26 August 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Methyl magnesium bromide is a catalyst for the dehydrocoupling of silanes and amines to produce aminosilane products under mild conditions. As a commercially available Grignard reagent, this catalyst represents a simplification over previous magnesium-containing catalysts for Si–N bond formation while displaying similar activity to other magnesium-based catalysts. This observation is consistent with the hypothesis that competitive Schlenk equilibrium can be addressed by not using an ancillary ligand. While the activity of MeMgBr is lower than some reported catalysts, including other commercially available catalysts, unique selectivity was observed for MeMgBr that may allow for selective synthesis of aminosilane products. This work continues to increase the accessibility of Si–N heterodehydrocoupling through a growing family of commercially available precatalysts that balance activity and selectivity.

Keywords

dehydrocoupling
amine
silane
Grignard
magnesium

Supplementary materials

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