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Development of Spectrophotometric Method for the Quantitative Determination of Betamethasone 17-Valerate in Creams

04 July 2024, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A simple spectrophotometric technique has been developed and validated for determination of betamethasone 17-valerate in pharmaceutical formulations. The method is based on cream dissolution in absolute ethanol and assaying spectrophotometrically at 240nm. The amount of betamethasone 17-valerate in cream was determined as 101.6 ± 0.0037 % w/w. The method validation demonstrated linearity for concentration range of 0.006mg/ml to 0.0014mg/ml (R2=0.9995). The method is simple and accurate and has successfully been employed in the analysis of some of Tripharm pharmaceutical formulations.

Keywords

HPLC
UV-Vis Spectroscopy
Betamethasone 17-Valerate

Supplementary materials

Title
Description
Actions
Title
Statistical calculations
Description
Statistical calculations for determining BV content in Cream Samples
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Comment number 1, Motiki Francis Beleme: Oct 21, 2024, 09:06

The article has been published. Thank you.

Version History

Jul 04, 2024 Version 2

Version Notes

The inclusion of the tittle, authors and affiliations in the supporting information document for better associations with the working paper submitted.

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-tnstx-v2
D O I: 10.26434/chemrxiv-2024-tnstx-v2 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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