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What impact does tautomerism have on drug properties and development?

27 May 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This mini-review reports on effects that tautomerism has on predicted and clinically observed small-molecule properties important for drug design and drug behaviour in the patient. We present examples of both pharmacokinetics and pharmacodynamics effects. The importance of tautomerism on drugs’ formulation and possible interconversion of stereoisomers is also discussed.

Keywords

Tautomerism
Pharmacokinetics
Pharmacodynamics
Drug design
Drug properties

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Now Published

What impact does tautomerism have on drug discovery and development? [opens in a new tab]
Devendra K. Dhaked, Marc C. Nicklaus journal article
Expert Opinion on Drug Discovery
Online publication date: Jul 16, 2024

Version History

May 27, 2024 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-pfz2n
D O I: 10.26434/chemrxiv-2024-pfz2n [opens in a new tab]

Funding

NCI, NIH, Intramural Research Program
N/A
Department of Pharmacoinformatics, NIPER
N/A

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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