A comprehensive review on the synthesis of mangiferin derivatives and their multiple biological activities

Mangiferin, a chemically, oxygen and hydroxyl containing heterocycle and biologically versatile nucleus, has drawn more attention from traditional to modern medicinal chemists in the drug design and synthesis of novel drugs with their pharmacological properties, including anticancer, anti-inflammatory, neuroprotective, antidiabetic, analgesic, antimalarial, anticonvulsant, laxative, cardiotonic, hemopoietic, antioxidant, antimicrobial, antipsychotic, anticoagulant, and antihypertensive properties. This review basically focuses on a detailed and updated overview of mangiferin derivatives, and their diverse biological activities, with examples from both patented and non-patented literature.