Tuning and Matching Error Compensated, Quantitative Solid-state NMR

Abstract NMR spectroscopy has long been recognized as a powerful quantitative analytical tool. Quantification is commonly done against internal and external standards. A third approach is to quantify against an electronic reference which combines the advantages of the two methods. The implementation of this approach in solid-state NMR is more challenging due to the single-coil design of double resonance probes. In this study, a novel approach for implementing the electronic referencing method in solid-state NMR by injecting the reference signal using a broadband antenna installed near the NMR receiver coil is presented. This method demonstrates excellent accuracy and precision, as it remains robust to changes in the electronic conditions of the probe, including tuning and matching errors.