Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

N-Heterocyclic carbene-catalyzed SuFEx reactions of functionalized secondary alcohols

16 February 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An organocatalytic Sulfur (VI)-fluoride exchange (SuFEx) reaction of secondary alcohols is reported. Under the catalysis of 10 mol% NHC/MS 4Å, both trifluoromethyl and difluoromethyl benzyl alcohols reacted with aryl sulfonyl fluorides to produce the corresponding sulfonates in moderate to high yields.

Keywords

N-Heterocyclic carbene
Sulfur (VI) fluoride exchange
click chemistry
sulfonates
secondary alcohols

Supplementary materials

Title
Description
Actions
Title
Supporting Information
Description
Includes general information, general procedure for the synthesis of sulfonates and copies of NMR spectra.
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Feb 16, 2024 Version 1

Metrics

527
403
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-11wql
D O I: 10.26434/chemrxiv-2024-11wql [opens in a new tab]

Funding

National Natural Science Foundation of China
21662029

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share