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N-Heterocyclic carbene-catalyzed SuFEx reactions of functionalized secondary alcohols

16 February 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An organocatalytic Sulfur (VI)-fluoride exchange (SuFEx) reaction of secondary alcohols is reported. Under the catalysis of 10 mol% NHC/MS 4Å, both trifluoromethyl and difluoromethyl benzyl alcohols reacted with aryl sulfonyl fluorides to produce the corresponding sulfonates in moderate to high yields.

Keywords

N-Heterocyclic carbene
Sulfur (VI) fluoride exchange
click chemistry
sulfonates
secondary alcohols

Supplementary materials

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Description
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Supporting Information
Description
Includes general information, general procedure for the synthesis of sulfonates and copies of NMR spectra.
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Version History

Feb 16, 2024 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-11wql
D O I: 10.26434/chemrxiv-2024-11wql [opens in a new tab]

Funding

National Natural Science Foundation of China
21662029

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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