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Decarboxylative C N coupling of 2,2-difluorobicyclo[1.1.1]pentane (BCP-F2) building blocks

18 December 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Described herein is our effort towards achieving the decarboxylative functionalization of 2,2-difluorobicyclo[1.1.1]pentane (BCP-F2) building blocks. When compared with the non-fluorinated bicyclo[1.1.1]pentane (BCP) analogues, we discovered divergent reactivities. This is the first successful decarboxylative coupling of BCP-F2 building blocks reported via photoredox mechanism.

Keywords

BCP-F2
Decarboxylative coupling
C-N coupling
Photoredox
Heterocycle

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Version History

Dec 18, 2023 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-9nqnw
D O I: 10.26434/chemrxiv-2023-9nqnw [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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