Fabrication and Characterization of Tamarind gum–Hydroxypropyl-beta-cyclodextrin-based semi-interpenetrating hydrogel network and In-vitro release of Moxifloxacin

Interpenetrating networks of hydroxypropyl-beta-cyclodextrin have shown great potential as drug carriers showing controlled release characteristics. In this study, we report the formation of a semi-interpenetrating hydrogel network between tamarind gum and hydroxypropyl-beta-cyclodextrin for the sustained release of moxifloxacin. The prepared hydrogels were characterized for their morphology, crystal structure, chemical composition, electrical, mechanical, drug release, and antibacterial properties. Microscopic studies revealed the formation of globular structures that were concentration dependent. XRD and FTIR studies indicated the hydrogen bonding among the TG–HPβCD molecules and rendered the formation of IPN. Electrical and mechanical studies revealed that the properties of the hydrogels were highly dependent on the HPβCD concentration. The in-vitro drug release depicted non-Fickian behavior of the drug release. Antibacterial studies revealed that the drug was actively released from the IPN system and was effective against Escherichia coli.