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Abstract
The use of three-dimensional self-assembled metallacages (MCgs) as theranostic platforms holds great promise. This work reports on the integration of a gold(III) porphyrin scaffold into a prismatic metallacage structure and explores its application for photodynamic therapy (PDT) of cancer in vitro. Not only the new metallacage retains the photosensitizing properties of the gold porphyrin, but unexpectedly, it also shows remarkable selective stabilization of guanine-quadruplexes (G4) structures as validated anticancer drug targets.
Supplementary materials
Title
SI_Gold metallacages
Description
Experimental methods, and supplementary data:
NMR spectra, MS spectra, UV-Visible absorption spectra, stability studies, additional figures and tables.
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