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Fe-Electrocatalytic Deoxygenative Giese Reaction

29 September 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A redox-neutral Fe-electrocatalytic deoxygenative Giese reaction is reported. Hydroxyl groups are among the most abundant functional groups. The advancement of efficient conversion reactions holds significant importance in medicinal and process chemistry. In this report, we present a redox-neutral Giese reaction via anodic oxidation to generate phosphonium ions and cathodic reduction to yield low-valent Fe catalysts. This reaction constitutes a ground-breaking account of a redox-neutral reaction utilizing Fe-catalyst and electrochemistry. It will facilitate the exploration of diverse novel reactions employing this redox cycle in the future.

Keywords

electrochemistry
Fe-catalyst
Deoxygenative Giese Reaction

Supplementary materials

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Supporting Information
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Experimental Procedures and Characterization of Compounds
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Version History

Sep 29, 2023 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-xpc2f
D O I: 10.26434/chemrxiv-2023-xpc2f [opens in a new tab]

Funding

HKUST start-up funds
Project No. R9820
AMED and the New York Academy of Sciences
Interstellar Initiative Early Career Program

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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