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Sulfamate Tethered Aza-Wacker Strategy for a Kasugamine Synthon

21 September 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We present our preparation of a kasugamine synthon, which proceeds in 14 steps from a literature epoxide. We expect that this kasugamine derivative can be used for the total syntheses of kasugamycin, minosaminomycin, and analogue antibiotics. A key step in the synthesis is our laboratory’s sulfamate-tethered aza-Wacker cyclization.

Supplementary materials

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Version History

Sep 21, 2023 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-knbbh
D O I: 10.26434/chemrxiv-2023-knbbh [opens in a new tab]

Funding

National Institutes of Health
R35GM142499
National Institutes of Health
P30GM145499

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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