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Synthesis and Base Pairing Properties of Platinum(II) Nucleosides Based on Uracil

18 September 2023, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The synthesis and base pairing properties of platinum complexes based on uridine and deoxyuridine nucleosides are described. The synthesis was performed by C–I oxidative addition with protected and unprotected nucleosides. The metallated compounds feature an agostic interaction at H6. Uridine complexes undergo self-base pairing and also establish base pairs with adenosine. The formation of an intermolecular N-H-Pt bond is also observed

Keywords

organometallic nucleosides
base pairs
uracil
oxidative addition
platinum

Supplementary materials

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supporting information
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synthetic procedures and characterization
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Now Published

Synthesis, Base Pairing Properties, and Biological Activity Studies of Platinum(II) Complexes Based on Uracil Nucleosides [opens in a new tab]
Maria Inês P. S. Leitão, Giulia Orsini, Fernanda Murtinheira, Clara S. B. Gomes, Federico Herrera, Ana Petronilho journal article
Inorganic Chemistry , Volume 62, Issue 40
Online publication date: Sep 28, 2023

Version History

Sep 18, 2023 Version 2

Version Notes

Corrected version of NMR interpretation

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-6k01r-v2
D O I: 10.26434/chemrxiv-2022-6k01r-v2 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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