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Abstract
Kinetic model of excitatory synapse functioning with glutamate and N-acetylaspartylglutamate (NAAG) as neurotransmitters in a three-component system regarding neuroglial astrocytic cells and the glutamate carboxypeptidase (GCPII) enzyme has been developed. The biphasic nature of the process providing excitation amplification within the modeling framework is shown. The role of excitatory synapse intensity has been investigated. The role of NAAG for enhancing neuronal connectivity and the realization of cognitive function is shown. The mechanism of cognition control by influencing on the efficiency of mGluR3 metabotropic receptor functioning is dis-cussed. The role of GCPII inhibition as a method of improving cognitive functions is studied. Dynamic features of the glutamatergic system behavior in neurodegenerative diseases (Alzheimer's disease, dementia), schizophrenia, traumatic brain injury, and epilepsy, as a part of development of the kinetic model are analyzed. The positive role of GCPII inhibition with the NAAG level increase as an effective approach to neuropathology treatment is shown.
