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Qualitative monitoring of proto-peptide condensation by differential FTIR spectroscopy

04 September 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Condensation processes such as wet-dry cycling are thought to have played significant roles in the emergence of proto-peptides. Here, we describe a simple and low-cost method, differential Fourier transform infrared (FTIR) spectroscopy, for qualitative analysis of peptide condensation products in model primordial reactions. This method is optimized for depsipeptides and is used to investigate their polymerization in the presence of extraterrestrial dust simulants.

Keywords

FTIR
wet-dry cycling
depsipeptides
prebiotic chemistry
astrobiology

Supplementary materials

Title
Description
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Title
Supplemental Information
Description
FTIR and MALDI-TOF MS data.
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Now Published

Qualitative Monitoring of Proto-Peptide Condensation by Differential FTIR Spectroscopy [opens in a new tab]
Keon Rezaeerod, Hanna Heinzmann, Alexis V. Torrence, Jui Patel, Jay G. Forsythe journal article
ACS Earth and Space Chemistry
Online publication date: May 06, 2024

Version History

Sep 04, 2023 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-hlfmp
D O I: 10.26434/chemrxiv-2023-hlfmp [opens in a new tab]

Funding

NSF
CHE-1504217
NIH SC INBRE
P20GM103499-20
NASA SC EPSCoR

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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