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Abstract
This paper describes the development and performance of catalytic crane-like DNA nanostructures for the controlled modification of wild-type proteins. We show that the position of the catalyst offers control over the site of modification, and that reversible interactions between the catalytic structure and thrombin enable trigger-responsive modification in complex mixtures.
Supplementary materials
Title
Catalytic DNA Nanocranes for Controlled Protein Modification in Cell Lysate
Description
Detailed description of the materials that were used, synthetic and analytical procedures that were followed for the preparation of small molecules and relevant bioconjugates, analysis results of the DNA modification reactions and protein modification studies.
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