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Total Synthesis of Sclerotioloid A

27 July 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A four-step total synthesis of a structurally unique N-propargyllated 2,5-diketopiperazine alkaloid sclerotioloid A has been achieved. Structural studies point towards sclerotioloid A being a helically chiral racemate in the solid state.

Keywords

total synthesis
diketopiperazine
alkaloid
helical chirality

Supplementary materials

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Supporting information
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Experimental protocols and spectroscopic data.
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Version History

Jul 27, 2023 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-qb8g3
D O I: 10.26434/chemrxiv-2023-qb8g3 [opens in a new tab]

Funding

Aalto University

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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